Evidence map›Paper›PMID 24550984›Full record

ArticleInternational journal of endocrinology2014

Reduced Seminal Concentration of CD45pos Cells after Follicle-Stimulating Hormone Treatment in Selected Patients with Idiopathic Oligoasthenoteratozoospermia.

Rosita A Condorelli, Aldo E Calogero, Enzo Vicari, Laura Mongioi', Giovanni Burgio, Rossella Cannarella, Filippo Giacone, Linda Iacoviello, Giuseppe Morgia, Vincenzo Favilla and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rosita A CondorelliDepartment of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.
Aldo E CalogeroDepartment of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.
Enzo VicariDepartment of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.
Laura Mongioi'Department of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.
Giovanni BurgioDepartment of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.ORCID 0000-0002-8099-0782
Rossella CannarellaDepartment of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.
Filippo GiaconeDepartment of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.
Linda IacovielloDepartment of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.
Giuseppe MorgiaDepartment of Urology, University of Catania, Catania, Italy.ORCID 0000-0002-7224-7577
Vincenzo FavillaDepartment of Urology, University of Catania, Catania, Italy.
Sebastiano CiminoDepartment of Urology, University of Catania, Catania, Italy.ORCID 0000-0002-6045-3373
Sandro La VigneraDepartment of Medical and Pediatric Sciences, Section of Endocrinology, Andrology and Internal Medicine, University of Catania, Policlinico "G. Rodolico", Building 4, Rm 2C18, Via S. Sofia 78, 95123 Catania, Italy.
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study evaluated the conventional sperm parameters and the seminal concentration of CD45pos cells (pan-leukocyte marker) of infertile patients with idiopathic oligoasthenoteratozoospermia (OAT). The patients were arbitrarily divided into three groups treated with recombinant follicle-stimulating hormone FSH: α (Group A = 20 patients), recombinant FSH- β (Group B = 20 patients), and highly purified human FSH (Group C = 14 patients). All treated groups achieved a similar improvement of the main sperm parameters (density, progressive motility, and morphology), but only the increase in the percentage of spermatozoa with normal morphology was significant compared to the baseline in all three examined groups. Moreover, all groups had a significant reduction of the seminal concentration of CD45pos cells and of the percentage of immature germ cells. Before and after the treatment, the concentration of CD45pos cells showed a positive linear correlation with the percentage of immature germ cells and a negative correlation with the percentage of spermatozoa with regular morphology. These results demonstrate that treatment with FSH is effective in patients with idiopathic OAT and that there are no significant differences between the different preparations. The novelty of this study is in the significant reduction of the concentration of CD45pos cells observed after the treatment.

Identifiers

PMID24550984
PMCPMC3914479
OpenAlexW2011944660

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.