ArticlePakistan journal of medical sciences2013
Relationship of high sensitivity C-reactive protein with presence and severity of coronary artery disease.
Article in Pakistan journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- National Heart Center/Saudi Heart Association 2025 Guidelines for Cardiovascular Diseases Prevention and Risk Assessment.Saudi medical journal · 2026Guideline
- Risk factors, lab parameters, angiographic characteristics and outcomes of coronary artery disease in young South Asian patients: a systematic review.The Journal of international medical research · 2023Pooled it
- Article
- Elevated Inflammation and Adhesion Molecule hsCRP, GDF-15 and VCAM-1 in Angina Patients with Non-obstructive Coronary Artery Disease.The Malaysian journal of medical sciences : MJMS · 2024Article
- Article
- Exploring of gut microbiota features in dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography.Frontiers in microbiology · 2024Article
- Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.European heart journal open · 2023Article
- Biomarkers for Premature Coronary Artery Disease (PCAD): A Case Control Study.Diagnostics (Basel, Switzerland) · 2023Article
- Novel Adiponectin-Resistin Indices and Ratios Predict Increased Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus.Journal of the Saudi Heart Association · 2023Article
- A Coronary Artery Disease Monitoring Model Built from Clinical Data and Alpha-1-Antichymotrypsin.Diagnostics (Basel, Switzerland) · 2022Article
- Associations between IL-6 and Echo-Parameters in Patients with Early Onset Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2019Article
- Cardiovascular Risk and Neurocognitive Assessment in Young Adults and Their Relationship to Body Adiposity.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Genetic Markers for Coronary Artery Disease.Medicina (Kaunas, Lithuania) · 2018Review
- The relationship between serum levels of hs-CRP and coronary lesion severity.Clujul medical (1957) · 2016Article
- The role of hs-CRP, D-dimer and fibrinogen in differentiating etiological subtypes of ischemic stroke.PloS one · 2015Article
- Association of Serum Pentraxin 3 and High-Sensitivity C-Reactive Protein with Severity of Coronary Stenosis.International journal of applied & basic medical researchArticle
- Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification.Pakistan journal of medical sciencesArticle
- Association of Elevated Levels of Inflammatory Marker High-Sensitivity C-Reactive Protein and Hypertension.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInflammation plays a key role in the pathogenesis of atherosclerosis. This study aimed to assess the relationship of serum inflammatory marker high sensitivity C Reactive protein (hsCRP), with the presence and severity of angiographically evaluated coronary artery disease (CAD).
methodsThis study was conducted at departments of physiology and cardiology, College of Medicine & King Khalid University Hospital, King Saud University, Riyadh from August 2009 to March 2012. Eighty seven patients (57 males and 30 females) with angiographically evaluated CAD were studied. In all these patients CAD severity was assessed by Gensini scoring and vessel scoring. Control group consisted of 29 healthy subjects (17 males and 12 females). Fasting venous blood samples were analyzed for lipid profile and high sensitivity C-reactive protein (hsCRP).
resultsThere were non-significant differences in age, weight and BMI among healthy subjects and CAD patients. Comparison of lipid profile between control and CAD patients showed that CAD patients had significantly higher TG and significantly lower HDL levels compared to control subjects. CAD patients presented with significantly higherhsCRP levels than controls. Linear regression analysis between hsCRP and CAD severity determined by Gensini scores showed a significant positive correlation (r=0.423, p=0.018). Triple vessel disease patients had significantly higher hsCRP levels than one vessel and two vessel disease, while the difference was non significant between one and two vessel disease groups.
conclusionsThese results suggest that patients with angiographically evaluated CAD have significantly higher levels of hsCRP levels compared to healthy individuals and are correlated with the presence & severity of CAD.
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