ArticlePakistan journal of medical sciences2013
Identification and antibiotic susceptibility pattern of coagulase-negative staphylococci in various clinical specimens.
Article in Pakistan journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antibiotic resistance in Pakistan: a systematic review of past decade.BMC infectious diseases · 2021Pooled it
- Article
- Antibiotic Resistance andInfection and drug resistance · 2020Article
- Association of intercellular adhesion gene A with biofilm formation in staphylococci isolates from patients with conjunctivitis.Journal of laboratory physiciansArticle
- Assessment of inducible clindamycin resistance and Hyper Variable Region (HVR) ofPakistan journal of medical sciencesArticle
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Abstract
objectiveAntibiotic resistance is a global problem and is more prevalent in developing countries. Coagulase-negative staphylococci (CoNS) are recognized as important pathogen for nosocomial infections. This study was carried out to identify CoNS in various clinical specimens and to determine its antimicrobial susceptibility pattern.
methodsA total of 2989 specimens of blood, pus and wound swab were collected from wards, casualty, ICU and OPD, out of these, staphylococci were isolated in 1000 specimens, of which 381 were identified as CoNS. Culture, gram stain, catalase, coagulase test and antimicrobial susceptibility pattern were done according to clinical manual of microbiology. A total of fourteen antibiotics were used in this study. Susceptibility testing was done by Kirby Bauer disc diffusion technique.
resultsAntimicrobial resistance of CoNS were Oxacillin (70.3%), Amoxicillin (74.8%), Amoxicillin+clavulanate (32.8%), Ciprofloxacin (35.2%), Ofloxacin (33.6%), Ceftriaxone (30.4%), Erythromycin (58.3%), Clindamycin (16.3%), Daptomycin (42.5%), Kanamycin (52.2%), Fusidic acid (41.7%), Doxycycline (24.7%), Vancomycin (2.6%) and Linezolid (0.8%). Maximum Oxacillin resistance was between 80 to 90 percent in a group of patients having age of 45 to 65 years and those suffering from cancer or admitted in ICU.
conclusionThe study concluded that CoNS showed significant level of resistance against most of the widely used therapeutic agents.
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