ArticleFrontiers in plant science2014
Significant role of PB1 and UBA domains in multimerization of Joka2, a selective autophagy cargo receptor from tobacco.
Article in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Dual roles of AtNBR1 in regulating selective autophagyAutophagy · 2024Article
- LSU family members and NBR1 are novel factors that contribute to homeostasis of catalases and peroxisomes in Arabidopsis thaliana.Scientific reports · 2024Article
- Autophagy receptor OsNBR1 modulates salt stress tolerance in rice.Plant cell reports · 2023Article
- Article
- Engineering Resistance againstPlants (Basel, Switzerland) · 2022Article
- Selective autophagy: adding precision in plant immunity.Essays in biochemistry · 2022Article
- Creativity comes from interactions: modules of protein interactions in plants.The FEBS journal · 2022Review
- Cellular Control of Protein Turnover via the Modification of the Amino Terminus.International journal of molecular sciences · 2021Review
- UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis.Nature plants · 2021Article
- AtNBR1 Is a Selective Autophagic Receptor for AtExo70E2 in Arabidopsis.Plant physiology · 2020Article
- A selective autophagy cargo receptor NBR1 modulates abscisic acid signalling in Arabidopsis thaliana.Scientific reports · 2020Article
- Deep Evolutionary History of the Phox and Bem1 (PB1) Domain Across Eukaryotes.Scientific reports · 2020Article
- Poplar Autophagy Receptor NBR1 Enhances Salt Stress Tolerance by Regulating Selective Autophagy and Antioxidant System.Frontiers in plant science · 2020Article
- Membrane Contact Sites and Organelles Interaction in Plant Autophagy.Frontiers in plant science · 2020Review
- Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins.Journal of experimental botany · 2020Article
- Autophagic Machinery of Plant Peroxisomes.International journal of molecular sciences · 2019Review
- Proximity-dependent biotinylation screening identifies NbHYPK as a novel interacting partner of ATG8 in plants.BMC plant biology · 2019Article
- The role of protein-protein interactions mediated by the PB1 domain of NLP transcription factors in nitrate-inducible gene expression.BMC plant biology · 2019Article
- Review
- Bacteria Exploit Autophagy for Proteasome Degradation and Enhanced Virulence in Plants.The Plant cell · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tobacco Joka2 protein is a hybrid homolog of two mammalian selective autophagy cargo receptors, p62 and NBR1. These proteins can directly interact with the members of ATG8 family and the polyubiquitinated cargoes designed for degradation. Function of the selective autophagy cargo receptors relies on their ability to form protein aggregates. It has been shown that the N-terminal PB1 domain of p62 is involved in formation of aggregates, while the UBA domains of p62 and NBR1 have been associated mainly with cargo binding. Here we focus on roles of PB1 and UBA domains in localization and aggregation of Joka2 in plant cells. We show that Joka2 can homodimerize not only through its N-terminal PB1-PB1 interactions but also via interaction between N-terminal PB1 and C-terminal UBA domains. We also demonstrate that Joka2 co-localizes with recombinant ubiquitin and sequestrates it into aggregates and that C-terminal part (containing UBA domains) is sufficient for this effect. Our results indicate that Joka2 accumulates in cytoplasmic aggregates and suggest that in addition to these multimeric forms it also exists in the nucleus and cytoplasm in a monomeric form.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.