ReviewFrontiers in immunology2014
Hiding in Plain Sight: Interplay between Staphylococcal Biofilms and Host Immunity.
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 173 citations in OpenAlex.
- An All-in-One Nanoplatform for Synergistic Anti-Infection and Healing of Diabetic Wounds via Photothermal-Gas Therapy.Advanced healthcare materials · 2026Article
- [Chronic MRSA periprosthetic joint infection induces formation of mature tertiary lymphoid structures and osteolysis in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Article
- Routine intraoperative infection testing in presumed aseptic hip and knee revision: a matched cohort retrospective study.Archives of orthopaedic and trauma surgery · 2026Article
- Pharmacophore- and QSAR-guided discovery of natural product inhibitors targeting dehydrosqualene synthase in Staphylococcus aureus.PloS one · 2026Article
- Host-pathogen interaction in community-acquired pneumonia: a focus on the immune response.Frontiers in cellular and infection microbiology · 2026Review
- Review
- Beneficial perspective onFrontiers in immunology · 2025Review
- Staphylococcus epidermidis alters macrophage polarization and phagocytic uptake by extracellular DNA release in vitro.NPJ biofilms and microbiomes · 2024Article
- Staphyloccocus aureus biofilm, in absence of planktonic bacteria, produces factors that activate counterbalancing inflammatory and immune-suppressive genes in human monocytes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Application of biofilm dispersion-based nanoparticles in cutting off reinfection.Applied microbiology and biotechnology · 2024Review
- Engineering antibacterial bioceramics: Design principles and mechanisms of action.Materials today. Bio · 2024Review
- Biofilms in Periprosthetic Orthopedic Infections Seen through the Eyes of Neutrophils: How Can We Help Neutrophils?International journal of molecular sciences · 2023Review
- Upregulation ofMicroorganisms · 2023Article
- Maternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications.Children (Basel, Switzerland) · 2023Review
- Interaction of Bacteria, Immune Cells, and Surface Topography in Periprosthetic Joint Infections.International journal of molecular sciences · 2023Article
- Article
- The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies.Antibiotics (Basel, Switzerland) · 2023Review
- The effect ofFrontiers in immunology · 2023Review
- Battle royale: Immune response on biofilms - host-pathogen interactions.Current research in immunology · 2023Review
- Phenotypic and Molecular Detection of Biofilm Formation in Methicillin-ResistantMediterranean journal of hematology and infectious diseases · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Staphylococcus aureus and Staphylococcus epidermidis are notable for their propensity to form biofilms on implanted medical devices. Staphylococcal biofilm infections are typified by their recalcitrance to antibiotics and ability to circumvent host immune-mediated clearance, resulting in the establishment of chronic infections that are often recurrent in nature. Indeed, the immunomodulatory lifestyle of biofilms seemingly shapes the host immune response to ensure biofilm engraftment and persistence in an immune competent host. Here, we provide a brief review of the mechanisms whereby S. aureus and S. epidermidis biofilms manipulate host-pathogen interactions and discuss the concept of microenvironment maintenance in infectious outcomes, as well as speculate how these findings pertain to the challenges of staphylococcal vaccine development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.