Evidence map›Paper›PMID 24550917›Full record

ArticleFrontiers in immunology2014

Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood.

Michelle A Neller, Brigitte Santner-Nanan, Rebekah M Brennan, Peter Hsu, Steven Joung, Ralph Nanan, Scott R Burrows, John J Miles

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michelle A NellerHuman Immunity Laboratory and Cellular Immunology Laboratory, QIMR Berghofer Medical Research Institute , Brisbane, QLD , Australia.
Brigitte Santner-NananNepean Centre for Perinatal Care, Sydney Medical School, The University of Sydney , Sydney, NSW , Australia.
Rebekah M BrennanHuman Immunity Laboratory and Cellular Immunology Laboratory, QIMR Berghofer Medical Research Institute , Brisbane, QLD , Australia.
Peter HsuNepean Centre for Perinatal Care, Sydney Medical School, The University of Sydney , Sydney, NSW , Australia.
Steven JoungNepean Centre for Perinatal Care, Sydney Medical School, The University of Sydney , Sydney, NSW , Australia.
Ralph NananNepean Centre for Perinatal Care, Sydney Medical School, The University of Sydney , Sydney, NSW , Australia.
Scott R BurrowsHuman Immunity Laboratory and Cellular Immunology Laboratory, QIMR Berghofer Medical Research Institute , Brisbane, QLD , Australia ; School of Medicine, The University of Queensland , Brisbane, QLD , Australia.
John J MilesHuman Immunity Laboratory and Cellular Immunology Laboratory, QIMR Berghofer Medical Research Institute , Brisbane, QLD , Australia ; School of Medicine, The University of Queensland , Brisbane, QLD , Australia ; Institute of Infection and Immunity, Cardiff University School of Medicine , Cardiff , UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human T cell compartment is a complex system and while some information is known on repertoire composition and dynamics in the peripheral blood, little is known about repertoire composition at different anatomical sites. Here, we determine the T cell receptor beta variable (TRBV) repertoire at the decidua and compare it with the peripheral blood during normal pregnancy and pre-eclampsia. We found total T cell subset disparity of up to 58% between sites, including large signature TRBV expansions unique to the fetal-maternal interface. Defining the functional nature and specificity of compartment-specific T cells will be necessary if we are to understand localized immunity, tolerance, and pathogenesis.

Indexed as

decidual mononuclear cellspre-eclampsiapregnancyT cell repertoire

Identifiers

PMID24550917
PMCPMC3913911

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.