ReviewFrontiers in immunology2014
Polarized cells, polarized views: asymmetric cell division in hematopoietic cells.
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Bone marrow-inspired DLL1-presenting microparticles enhance asymmetric division and maintenance of mouse hematopoietic stem and progenitor cells.Stem cell reports · 2026Article
- Cell polarity: cell type-specific regulators, common pathways, and polarized vesicle transport.Leukemia · 2025Review
- RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.Nature communications · 2023Article
- Phenotyping polarization dynamics of immune cells using a lipid droplet-cell pairing microfluidic platform.Cell reports methods · 2022Article
- Par-3 family proteins in cell polarity & adhesion.The FEBS journal · 2022Review
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- Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges.Frontiers in cell and developmental biology · 2021Article
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- Article
- Polarity as a physiological modulator of cell function.Frontiers in bioscience (Landmark edition) · 2019Review
- Model-Based Assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-Cell Immune Responses.Frontiers in immunology · 2019Article
- Neural Crossroads in the Hematopoietic Stem Cell Niche.Trends in cell biology · 2018Review
- Matrix Stiffness Modulates Mesenchymal Stem Cell Sensitivity to Geometric Asymmetry Signals.Annals of biomedical engineering · 2018Article
- Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.Methods in molecular biology (Clifton, N.J.) · 2018Article
- The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.Blood · 2017Article
- The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation.PloS one · 2017Article
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- Clonal expansion under the microscope: studying lymphocyte activation and differentiation using live-cell imaging.Immunology and cell biology · 2016Review
- Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.Immunology and cell biology · 2016Article
- Asymmetric cell division during T cell development controls downstream fate.The Journal of cell biology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has long been recognized that alterations in cell shape and polarity play important roles in coordinating lymphocyte functions. In the last decade, a new aspect of lymphocyte polarity has attracted much attention, termed asymmetric cell division (ACD). ACD has previously been shown to dictate or influence many aspects of development in model organisms such as the worm and the fly, and to be disrupted in disease. Recent observations that ACD also occurs in lymphocytes led to exciting speculations that ACD might influence lymphocyte differentiation and function, and leukemia. Dissecting the role that ACD might play in these activities has not been straightforward, and the evidence to date for a functional role in lymphocyte fate determination has been controversial. In this review, we discuss the evidence to date for ACD in lymphocytes, and how it might influence lymphocyte fate. We also discuss current gaps in our knowledge, and suggest approaches to definitively test the physiological role of ACD in lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.