ArticleFrontiers in behavioral neuroscience2014
Genetic imaging of the association of oxytocin receptor gene (OXTR) polymorphisms with positive maternal parenting.
Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
- Parental brain responses to own and unknown children's emotional facial expressions: An fMRI study.Cognitive, affective & behavioral neuroscience · 2026Article
- Birthing parents' neural response to infant cry: moderating effects of oxytocin and perceived childhood care.Social cognitive and affective neuroscience · 2025Article
- Predicting oxytocin binding dynamics in receptor genetic variants through computational modeling.npj women's health · 2025Article
- Cumulative Genetic Scores Interact with Maternal and Paternal Parenting in Predicting Parent-Adolescent Cohesion and Conflict.Journal of youth and adolescence · 2024Article
- Neurobiological Correlates of Fatherhood During the Postpartum Period: A Scoping Review.Frontiers in psychology · 2022Article
- Oxytocin Receptor Gene Polymorphism in Lactating Dogs.Animals : an open access journal from MDPI · 2021Article
- Article
- The promiscuity of the oxytocin-vasopressin systems and their involvement in autism spectrum disorder.Handbook of clinical neurology · 2021Review
- Adrenocortical attunement, reactivity, and potential genetic correlates among parent-daughter dyads from low-income families.Developmental psychobiology · 2020Article
- Oxytocin receptor gene, childhood maltreatment and borderline personality disorder features among male inmates in China.BMC psychiatry · 2020Article
- Associations between oxytocin receptor gene (OXTR) polymorphisms, childhood trauma, and parenting behavior.Developmental psychology · 2019Observational
- Childhood adversity and parenting behavior: the role of oxytocin receptor gene polymorphisms.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Specific maternal brain responses to their own child's face: An fMRI meta-analysis.Developmental review : DR · 2019Article
- Neuromodulation of maternal circuits by oxytocin.Cell and tissue research · 2019Review
- A smartphone-based ecological momentary assessment of parental behavioral consistency: Associations with parental stress and child ADHD symptoms.Developmental psychology · 2018Article
- Youth temperament, harsh parenting, and variation in the oxytocin receptor gene forecast allostatic load during emerging adulthood.Development and psychopathology · 2017Article
- Imaging genetics in neurodevelopmental psychopathology.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Review
- Implicit association to infant faces: Genetics, early care experiences, and cultural factors influence caregiving propensities.Behavioural brain research · 2017Article
- Common variant in OXTR predicts growth in positive emotions from loving-kindness training.Psychoneuroendocrinology · 2016Article
- Oxytocin and parent-child interaction in the development of empathy among children at risk for autism.Developmental psychology · 2016Article
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundWell-validated models of maternal behavior in small-brain mammals posit a central role of oxytocin in parenting, by reducing stress and enhancing the reward value of social interactions with offspring. In contrast, human studies are only beginning to gain insights into how oxytocin modulates maternal behavior and affiliation.
methodsTo explore associations between oxytocin receptor genes and maternal parenting behavior in humans, we conducted a genetic imaging study of women selected to exhibit a wide range of observed parenting when their children were 4-6 years old.
resultsIn response to child stimuli during functional magnetic resonance imaging (fMRI), hemodynamic responses in brain regions that mediate affect, reward, and social behavior were significantly correlated with observed positive parenting. Furthermore, single nucleotide polymorphisms (SNPs) (rs53576 and rs1042778) in the gene encoding the oxytocin receptor were significantly associated with both positive parenting and hemodynamic responses to child stimuli in orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and hippocampus.
conclusionsThese findings contribute to the emerging literature on the role of oxytocin in human social behavior and support the feasibility of tracing biological pathways from genes to neural regions to positive maternal parenting behaviors in humans using genetic imaging methods.
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