ReviewFrontiers in neuroscience2014
Perinatal programming of emotional brain circuits: an integrative view from systems to molecules.
Review in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 141 citations in OpenAlex.
- Common metabolic, environmental, and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders.Frontiers in neurology · 2026Review
- Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus.Biological research · 2024Article
- Line- and sex-dependent effects of juvenile stress on contextual fear- and anxiety-related behavior in high- and low-alcohol-preferring mouse lines.Behavioural brain research · 2024Article
- Early life stress induces decreased expression of CB1R and FAAH and epigenetic changes in the medial prefrontal cortex of male rats.Frontiers in cellular neuroscience · 2024Article
- Developmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure.Frontiers in cellular neuroscience · 2023Article
- Maternal adverse childhood experiences and infant subcortical brain volume.Neurobiology of stress · 2022Article
- Early Life Stress-Induced Epigenetic Programming of Hippocampal NPY-Y2 Receptor Gene Expression Changes in Response to Adult Stress.Frontiers in cellular neuroscience · 2022Article
- Exposure to prenatal maternal distress and infant white matter neurodevelopment.Development and psychopathology · 2021Article
- Prenatal stress dysregulates resting-state functional connectivity and sensory motifs.Neurobiology of stress · 2021Article
- Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization.Neuroscience and biobehavioral reviews · 2021Review
- Maternal exposure to a high-magnitude earthquake during pregnancy influences pre-reading skills in early childhood.Scientific reports · 2021Article
- "Mombrain and Sticky DNA": The Impacts of Neurobiological and Epigenetic Framings of Motherhood on Women's Subjectivities.Frontiers in sociology · 2021Article
- StandardizedAntioxidants (Basel, Switzerland) · 2020Article
- Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring's brain and behavior.Neurobiology of stress · 2020Article
- Article
- Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse.Neurobiology of stress · 2020Article
- Maternal Prenatal Stress Is Associated With Altered Uncinate Fasciculus Microstructure in Premature Neonates.Biological psychiatry · 2020Article
- Positive Roles of Resveratrol in Early Development of Testicular Germ Cells against Maternal Restraint Stress in Mice.Animals : an open access journal from MDPI · 2020Article
- Moderate prenatal stress may buffer the impact of Superstorm Sandy on placental genes: Stress in Pregnancy (SIP) Study.PloS one · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental influences such as perinatal stress have been shown to program the developing organism to adapt brain and behavioral functions to cope with daily life challenges. Evidence is now accumulating that the specific and individual effects of early life adversity on the functional development of brain and behavior emerge as a function of the type, intensity, timing and the duration of the adverse environment, and that early life stress (ELS) is a major risk factor for developing behavioral dysfunctions and mental disorders. Results from clinical as well as experimental studies in animal models support the hypothesis that ELS can induce functional "scars" in prefrontal and limbic brain areas, regions that are essential for emotional control, learning and memory functions. On the other hand, the concept of "stress inoculation" is emerging from more recent research, which revealed positive functional adaptations in response to ELS resulting in resilience against stress and other adversities later in life. Moreover, recent studies indicate that early life experiences and the resulting behavioral consequences can be transmitted to the next generation, leading to a transgenerational cycle of adverse or positive adaptations of brain function and behavior. In this review we propose a unifying view of stress vulnerability and resilience by connecting genetic predisposition and programming sensitivity to the context of experience-expectancy and transgenerational epigenetic traits. The adaptive maturation of stress responsive neural and endocrine systems requires environmental challenges to optimize their functions. Repeated environmental challenges can be viewed within the framework of the match/mismatch hypothesis, the outcome, psychopathology or resilience, depends on the respective predisposition and on the context later in life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.