ArticlePLoS genetics2014
Sex-specific embryonic gene expression in species with newly evolved sex chromosomes.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Genomic resources for the scuttle fly Megaselia abdita: a model organism for comparative developmental studies in flies.Development (Cambridge, England) · 2025Article
- The role of unbalanced segmental duplication in sex chromosome evolution in Australian ridge-tailed goannas.Scientific reports · 2025Article
- Evidence for a Novel X Chromosome in Termites.Genome biology and evolution · 2024Article
- Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation.PLoS biology · 2024Article
- Article
- Continuous transcriptome analysis reveals novel patterns of early gene expression inCell genomics · 2023Article
- Article
- Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males.Nature communications · 2020Article
- Evolved Differences inGenetics · 2020Article
- The conserved regulatory basis of mRNA contributions to the early Drosophila embryo differs between the maternal and zygotic genomes.PLoS genetics · 2020Article
- Evolution of maternal and zygotic mRNA complements in the early Drosophila embryo.PLoS genetics · 2018Article
- Effect of Larval Nutrition on Maternal mRNA Contribution to theG3 (Bethesda, Md.) · 2018Article
- Alternative Splicing within and between Drosophila Species, Sexes, Tissues, and Developmental Stages.PLoS genetics · 2016Article
- Dosage Compensation in Drosophila-a Model for the Coordinate Regulation of Transcription.Genetics · 2016Review
- Primary Sex Determination in Drosophila melanogaster Does Not Rely on the Male-Specific Lethal Complex.Genetics · 2016Article
- Article
- Sex Bias and Maternal Contribution to Gene Expression Divergence in Drosophila Blastoderm Embryos.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sex chromosome dosage differences between females and males are a significant form of natural genetic variation in many species. Like many species with chromosomal sex determination, Drosophila females have two X chromosomes, while males have one X and one Y. Fusions of sex chromosomes with autosomes have occurred along the lineage leading to D. pseudoobscura and D. miranda. The resulting neo-sex chromosomes are gradually evolving the properties of sex chromosomes, and neo-X chromosomes are becoming targets for the molecular mechanisms that compensate for differences in X chromosome dose between sexes. We have previously shown that D. melanogaster possess at least two dosage compensation mechanisms: the well- characterized MSL-mediated dosage compensation active in most somatic tissues, and another system active during early embryogenesis prior to the onset of MSL-mediated dosage compensation. To better understand the developmental constraints on sex chromosome gene expression and evolution, we sequenced mRNA from individual male and female embryos of D. pseudoobscura and D. miranda, from ∼0.5 to 8 hours of development. Autosomal expression levels are highly conserved between these species. But, unlike D. melanogaster, we observe a general lack of dosage compensation in D. pseudoobscura and D. miranda prior to the onset of MSL-mediated dosage compensation. Thus, either there has been a lineage-specific gain or loss in early dosage compensation mechanism(s) or increasing X chromosome dose may strain dosage compensation systems and make them less effective. The extent of female bias on the X chromosomes decreases through developmental time with the establishment of MSL-mediated dosage compensation, but may do so more slowly in D. miranda than D. pseudoobscura. These results also prompt a number of questions about whether species with more sex-linked genes have more sex-specific phenotypes, and how much transcript level variance is tolerable during critical stages of development.
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