Evidence map›Paper›PMID 24550581›Full record

Trial reportIndian journal of pharmacology

Study of levosimendan during off-pump coronary artery bypass grafting in patients with LV dysfunction: a double-blind randomized study.

B Shah, P Sharma, A Brahmbhatt, R Shah, B Rathod, Naman Shastri, J Patel, A Malhotra

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 8 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 8 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

B ShahChief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, India.
P SharmaChief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, India.
A BrahmbhattChief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, India.
R ShahChief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, India.
B RathodChief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, India.
Naman ShastriChief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, India.
J PatelChief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, India.
A MalhotraChief Cardiac Anesthesiologist, SAL Hospital, Ahmadabad, Gujarat, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesLevosimendan is a calcium sensitizer drug which has been used in cardiac surgery for the prevention of postoperative low cardiac output syndrome (LCOS) and in difficult weaning from cardiopulmonary bypass (CPB). This study aims to evaluate perioperative hemodynamic effects of levosimendan pretreatment in patients for off-pump coronary artery bypass graft (OPCABG) surgery with low left ventricular ejection fractions (LVEF < 30%). MATERIALS AND

methodsFifty patients undergoing OPCABG surgery with low LVEF (<30%) were enrolled in the study. Patients were randomly divided in two groups: Levosimendan pretreatment (Group L) and placebo pretreatment (Group C) of 25 each. Group L, patients received levosimendan infusion 200 μg/kg over 24 h and in Group C Patients received placebo. The clinical parameters measured before and after the drug administration up to 48 h were heart rate (HR; for the hour after drug infusion), cardiac index (CI), and pulmonary capillary wedge pressure (PCWP). The requirement of inotropes, intraaortic balloon pump (IABP), CPB, intensive care unit (ICU) stay, and hospital stay were also measured.

resultsThe patients in group L exhibited higher CI and PCWP during operative in early postoperative period as compared to control group C. Group L also had a less requirement for inotropes, CPB support and IABP with shorter ICU stay as well as hospital stay.

conclusionLevosimendan pretreatment (24 h infusion) in patient for OPCABG with poor LVEF shows better outcomes and hemodynamics in terms of inotropes, CPB and IABP requirements. It also reduces ICU stay.

Indexed as

Coronary Artery BypassVentricular Function, LeftAgedCardiotonic AgentsCoronary Artery DiseaseDouble-Blind MethodFemaleHumansHydrazonesMaleMiddle AgedPostoperative ComplicationsPyridazinesSimendanCardiotonic AgentsHydrazonesPyridazinesSimendanCardiac indexCPBhemodynamic optimizationinotropic agentsLCOSlevosimendanoff-pump coronary artery bypass graftOPCABG surgerypulmonary capillary wedge pressure

Identifiers

PMID24550581
PMCPMC3912803
OpenAlexW1964644822

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.