ArticleProceedings of the National Academy of Sciences of the United States of America2014
Gene expression differences underlying genotype-by-genotype specificity in a host-parasite system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 161 citations in OpenAlex.
- Host Prior Exposure Augments Gene Expression Heterogeneity of Both Host and Pathogen During In Vivo Infection.Molecular ecology · 2026Article
- Host-associated beneficial gut microbiota boosts induced immunity and limits immune deployment costs in bumblebees.The Journal of animal ecology · 2026Article
- Chromosome-level genome assembly of trypanosomatid parasite Lotmaria passim links chromosome duplication and divergence with infection of honey bees.BMC genomics · 2025Article
- First genetic characterisation and phylogenetic analysis of Trichomonadida from Gallus gallus domesticus (Aves: Phasianidae) and its nematode parasite Heterakis gallinarum (Ascaridida: Heterakidae) in Tunisia.Folia parasitologica · 2025Article
- Host prior exposure augments heterogeneity in gene expression in both host and pathogen duringbioRxiv : the preprint server for biology · 2025Article
- The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host.BMC genomics · 2025Article
- Comparative Transcriptome Analysis ofVaccines · 2024Article
- A biological invasion modifies the dynamics of a host-parasite arms race.Proceedings. Biological sciences · 2024Article
- A simulated natural heatwave perturbs bumblebee immunity and resistance to infection.The Journal of animal ecology · 2024Article
- Signatures of adaptive decreased virulence of deformed wing virus in an isolated population of wild honeybees (Proceedings. Biological sciences · 2023Article
- Bulinus snails in the Lake Victoria Basin in Kenya: Systematics and their role as hosts for schistosomes.PLoS neglected tropical diseases · 2023Article
- Antimicrobial Activity of Apidermin 2 from the HoneybeeInsects · 2022Article
- Consuming sunflower pollen reduced pathogen infection but did not alter measures of immunity in bumblebees.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Effects of an alternative host on the prevalence and intensity of infection of a bumble bee parasite.Parasitology · 2022Article
- Interacting phenotypes and the coevolutionary process: Interspecific indirect genetic effects alter coevolutionary dynamics.Evolution; international journal of organic evolution · 2022Article
- Genetic variation and microbiota in bumble bees cross-infected by different strains of C. bombi.PloS one · 2022Article
- Simulated vector transmission differentially influences dynamics of two viral variants of deformed wing virus in honey bees (The Journal of general virology · 2021Article
- Invasion history shapes host transcriptomic response to a body-snatching parasite.Molecular ecology · 2021Article
- Higher mortality of the less suitable brown trout host compared to the principal Atlantic salmon host when infested with freshwater pearl mussel (Margaritifera margaritifera) glochidia.Parasitology research · 2021Article
- Examining adaptive evolution of immune activity: opportunities provided by gastropods in the age of 'omics'.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
In many systems, host-parasite evolutionary dynamics have led to the emergence and maintenance of diverse parasite and host genotypes within the same population. Genotypes vary in key attributes: Parasite genotypes vary in ability to infect, host genotypes vary in susceptibility, and infection outcome is frequently the result of both parties' genotypic identities. These host-parasite genotype-by-genotype (GH × GP) interactions influence evolutionary and ecological dynamics in important ways. Interactions can be produced through genetic variation; however, here, we assess the role of variable gene expression as an additional source of GH × GP interactions. The bumblebee Bombus terrestris and its trypanosome gut parasite Crithidia bombi are a model system for host-parasite matching. Full-transcriptome sequencing of the bumblebee host revealed that different parasite genotypes indeed induce fundamentally different host expression responses and host genotypes vary in their responses to the infecting parasite genotype. It appears that broadly and successfully infecting parasite genotypes lead to reduced host immune gene expression relative to unexposed bees but induce the expression of genes responsible for controlling gene expression. Contrastingly, a poorly infecting parasite genotype induced the expression of immunologically important genes, including antimicrobial peptides. A targeted expression assay confirmed the transcriptome results and also revealed strong host genotype effects. In all, the expression of a number of genes depends on the host genotype and the parasite genotype and the interaction between both host and parasite genotypes. These results suggest that alongside sequence variation in coding immunological genes, variation that controls immune gene expression can also produce patterns of host-parasite specificity.
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