ArticleProceedings of the National Academy of Sciences of the United States of America2014
NF-κB signaling mediates homeostatic maturation of new T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection.The Journal of experimental medicine · 2025Article
- Ndrg3 is a critical regulator of peripheral T cell maturation and homeostasis.Science advances · 2025Article
- NF-κB regulated expression of A20 controls IKK dependent repression of RIPK1 induced cell death in activated T cells.Cell death and differentiation · 2025Article
- Gene-level alignment of single-cell trajectories.Nature methods · 2025Article
- The NF-κB signaling network in the life of T cells.Frontiers in immunology · 2025Review
- Elucidating immune-related gene transcriptional programs via factorization of large-scale RNA-profiles.iScience · 2024Article
- Multi-organ single-cell transcriptomics of immune cells uncovered organ-specific gene expression and functions.Scientific data · 2024Article
- Immune system modulation in aging: Molecular mechanisms and therapeutic targets.Frontiers in immunology · 2022Review
- Article
- Article
- The interplay of BMP4 and IL‑7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia̸reperfusion.International journal of molecular medicine · 2018Article
- Reinterpreting recent thymic emigrant function: defective or adaptive?Current opinion in immunology · 2018Review
- TNF activation of NF-κB is essential for development of single-positive thymocytes.The Journal of experimental medicine · 2016Article
- An Essential Role for the Transcription Factor Runx1 in T Cell Maturation.Scientific reports · 2016Article
- T Cell Adolescence: Maturation Events Beyond Positive Selection.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- T cell-NF-κB activation is required for tumor control in vivo.Journal for immunotherapy of cancer · 2015Article
- Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.eLife · 2014Article
- Zap70 is essential for long-term survival of naive CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Interleukin (IL)-7 is critical for the maintenance of the peripheral T-cell compartment of the adaptive immune system. IL-7 receptor α (IL-7Rα) expression is subject to developmental regulation and new T cells induce expression as they leave the thymus, which is essential for their long-term survival. It is not understood how this expression is regulated. Here, we identify a role for the Nuclear Factor κ-B (NF-κB) signaling pathway in controlling expression of IL-7Rα in new T cells. Perturbations to NF-κB signaling, either by deletion of Inhibitor of Kappa-B Kinase-2 (IKK2) or by inhibiting Rel dimer activity, prevented normal IL-7Rα expression in new T cells. Defective IL-7Rα expression resulted in impaired survival and homeostatic cell division responses by T cells that could be attributed to their failure to express IL-7Rα normally. Surprisingly, NF-κB signaling was only required transiently in new T cells to allow their normal expression of IL-7Rα, because IKK2 deletion in mature T cells had no effect on IL-7Rα expression or their normal homeostatic responsiveness. Therefore, we identify a developmental function for NF-κB signaling in the homeostatic maturation of new T cells, by regulating IL-7Rα expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.