ArticleProceedings of the National Academy of Sciences of the United States of America2014
Linking toxicity and adaptive responses across the transcriptome, proteome, and phenotype of Chlamydomonas reinhardtii exposed to silver.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.
- Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis.Environmental science & technology · 2020Pooled it
- Metabolomic profiling of diatoms reveals distinct impacts of silver nanoparticles and ions.Environmental science. Nano · 2026Article
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- Multiomics Approach Reveals the Inhibitory Effects of Protocatechuic Acid on the Marine DinoflagellateMicroorganisms · 2026Article
- Transcriptomics Reveals an Energy-Saving Metabolic Switch in an Extremophilic Red MicroalgaInternational journal of molecular sciences · 2025Article
- Global omics study of Tetraselmis chuii reveals time-related metabolic adaptations upon oxidative stress.Applied microbiology and biotechnology · 2024Article
- Silver nanoparticles synthesized by probiotic bacteria and antibacterial role in resistant bacteria.AMB Express · 2023Article
- Selenium-binding Protein 1 (SBD1): A stress response regulator in Chlamydomonas reinhardtii.Plant physiology · 2022Article
- Biomarkers of nanomaterials hazard from multi-layer data.Nature communications · 2022Article
- Heavy metal-induced stress in eukaryotic algae-mechanisms of heavy metal toxicity and tolerance with particular emphasis on oxidative stress in exposed cells and the role of antioxidant response.Environmental science and pollution research international · 2022Review
- Is Genetic Engineering a Route to Enhance Microalgae-Mediated Bioremediation of Heavy Metal-Containing Effluents?Molecules (Basel, Switzerland) · 2022Review
- Identification, Characterization, and Expression Analysis of Carotenoid Biosynthesis Genes and Carotenoid Accumulation in Watercress (ACS omega · 2022Article
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- Molecular Characterization, Expression Analysis of Carotenoid, Xanthophyll, Apocarotenoid Pathway Genes, and Carotenoid and Xanthophyll Accumulation inPlants (Basel, Switzerland) · 2021Article
- Transcriptome and Metabolome Profiling of a Novel IsolateFrontiers in microbiology · 2021Article
- Metabolomics for early detection of stress in freshwater alga Poterioochromonas malhamensis exposed to silver nanoparticles.Scientific reports · 2020Article
- The comparison of transcriptomic response of green microalga Chlorella sorokiniana exposure to environmentally relevant concentration of cadmium(II) and 4-n-nonylphenol.Environmental geochemistry and health · 2020Article
- Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis ofChemical science · 2019Article
- Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli.PLoS biology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding mechanistic and cellular events underlying a toxicological outcome allows the prediction of impact of environmental stressors to organisms living in different habitats. A systems-based approach aids in characterizing molecular events, and thereby the cellular pathways that have been perturbed. However, mapping only adverse outcomes of a toxicant falls short of describing the stress or adaptive response that is mounted to maintain homeostasis on perturbations and may confer resistance to the toxic insult. Silver is a potential threat to aquatic organisms because of the increasing use of silver-based nanomaterials, which release free silver ions. The effects of silver were investigated at the transcriptome, proteome, and cellular levels of Chlamydomonas reinhardtii. The cells instigate a fast transcriptome and proteome response, including perturbations in copper transport system and detoxification mechanisms. Silver causes an initial toxic insult, which leads to a plummeting of ATP and photosynthesis and damage because of oxidative stress. In response, the cells mount a defense response to combat oxidative stress and to eliminate silver via efflux transporters. From the analysis of the perturbations of the cell's functions, we derived a detailed mechanistic understanding of temporal dynamics of toxicity and adaptive response pathways for C. reinhardtii exposed to silver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.