Evidence map›Paper›PMID 24550472›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2014

Cortisol shifts financial risk preferences.

Narayanan Kandasamy, Ben Hardy, Lionel Page, Markus Schaffner, Johann Graggaber, Andrew S Powlson, Paul C Fletcher, Mark Gurnell, John Coates

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Reducing debt improves psychological functioning and changes decision-making in the poor.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Trial
  3. Dopamine Receptor-Specific Contributions to the Computation of Value.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Trial
  4. Combined Effects of Glucocorticoid and Noradrenergic Activity on Loss Aversion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Trial
  5. Trial
  6. Article
  7. Opposing Roles of Testosterone and Cortisol in Prosocial Risk-Taking.Behavioral sciences (Basel, Switzerland) · 2026
    Article
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  12. Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Narayanan KandasamyInstitute of Metabolic Science, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.
Ben Hardy
Lionel Page
Markus Schaffner
Johann Graggaber
Andrew S Powlson
Paul C Fletcher
Mark Gurnell
John Coates

Funding

Wellcome Trust 095692
6 · The paper itself

Abstract

Risk taking is central to human activity. Consequently, it lies at the focal point of behavioral sciences such as neuroscience, economics, and finance. Many influential models from these sciences assume that financial risk preferences form a stable trait. Is this assumption justified and, if not, what causes the appetite for risk to fluctuate? We have previously found that traders experience a sustained increase in the stress hormone cortisol when the amount of uncertainty, in the form of market volatility, increases. Here we ask whether these elevated cortisol levels shift risk preferences. Using a double-blind, placebo-controlled, cross-over protocol we raised cortisol levels in volunteers over 8 d to the same extent previously observed in traders. We then tested for the utility and probability weighting functions underlying their risk taking and found that participants became more risk-averse. We also observed that the weighting of probabilities became more distorted among men relative to women. These results suggest that risk preferences are highly dynamic. Specifically, the stress response calibrates risk taking to our circumstances, reducing it in times of prolonged uncertainty, such as a financial crisis. Physiology-induced shifts in risk preferences may thus be an underappreciated cause of market instability.

Indexed as

Financial ManagementRisk-TakingAdultCross-Over StudiesFemaleHumansHydrocortisoneMaleSalivaSex FactorsStress, PhysiologicalHydrocortisone

Identifiers

PMID24550472
PMCPMC3948282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.