ArticleInvestigative ophthalmology & visual science2014
Inner retinal oxygen delivery and metabolism in streptozotocin diabetic rats.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Genetic Evidence Supporting a Causal Association Between mTORC1-Dependent Circulating Protein Levels and Diabetic Retinopathy.Translational vision science & technology · 2025Article
- Tocotrienol-rich fraction reduces retinal inflammation and angiogenesis in rats with streptozotocin-induced diabetes.BMC complementary medicine and therapies · 2023Article
- The role of the mTOR pathway in diabetic retinopathy.Frontiers in medicine · 2022Review
- Assessment of retinal oxygen metabolism, visual function, thickness and degeneration markers after variable ischemia/reperfusion in rats.Experimental eye research · 2021Article
- Relation of Retinal Oxygen Measures to Electrophysiology and Survival Indicators after Permanent, Incomplete Ischemia in Rats.Translational stroke research · 2020Article
- Retinal Physiology and Circulation: Effect of Diabetes.Comprehensive Physiology · 2020Review
- Alterations in Retinal Oxygen Delivery, Metabolism, and Extraction Fraction During Bilateral Common Carotid Artery Occlusion in Rats.Investigative ophthalmology & visual science · 2019Article
- Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina.International journal of molecular sciences · 2018Review
- A Model for Graded Retinal Ischemia in Rats.Translational vision science & technology · 2018Article
- Retinal oxygen extraction in individuals with type 1 diabetes with no or mild diabetic retinopathy.Diabetologia · 2017Article
- Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017Review
- Inner Retinal Oxygen Delivery, Metabolism, and Extraction Fraction in Ins2Akita Diabetic Mice.Investigative ophthalmology & visual science · 2016Article
- Shifts in retinal vessel diameter and oxygen saturation in Chinese type 2 diabetes mellitus patients.BMC ophthalmology · 2016Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- Light adaptation does not prevent early retinal abnormalities in diabetic rats.Scientific reports · 2016Article
- The effect of intravitreal vascular endothelial growth factor on inner retinal oxygen delivery and metabolism in rats.Experimental eye research · 2016Article
- Inner retinal oxygen metabolism in the 50/10 oxygen-induced retinopathy model.Scientific reports · 2015Article
- Oxygen delivery, consumption, and conversion to reactive oxygen species in experimental models of diabetic retinopathy.Redox biology · 2014Review
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Authors and funding
4 authors.
Funding
Abstract
purposeThe purpose of the study is to report global measurements of inner retinal oxygen delivery (DO2_IR) and oxygen metabolism (MO2_IR) in streptozotocin (STZ) diabetic rats.
methodsPhosphorescence lifetime and blood flow imaging were performed in rats 4 (STZ/4 wk; n = 10) and 6 (STZ/6 wk; n = 10) weeks following injection of STZ to measure retinal arterial (O2A) and venous (O2V) oxygen contents and total retinal blood flow (F). DO2_IR and MO2_IR were calculated from measurements of F and O2A and of F and the arteriovenous oxygen content difference, respectively. Data in STZ rats were compared to those in healthy control rats (n = 10).
resultsMeasurements of O2A and O2V were not significantly different among STZ/4 wk, STZ/6 wk, and control rats (P ≥ 0.28). Likewise, F was similar among all groups of rats (P = 0.81). DO2_IR measurements were 941 ± 231, 956 ± 232, and 973 ± 243 nL O2/min in control, STZ/4 wk, and STZ/6 wk rats, respectively (P = 0.95). MO2_IR measurements were 516 ± 175, 444 ± 103, and 496 ± 84 nL O2/min in control, STZ/4 wk, and STZ/6 wk rats, respectively (P = 0.37).
conclusionsGlobal inner retinal oxygen delivery and metabolism were not significantly impaired in STZ rats in early diabetes.
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