ArticleProceedings of the National Academy of Sciences of the United States of America2014
Light responses of primate and other mammalian cones.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
- Asymmetric activation of retinal ON and OFF pathways by AOSLO raster-scanned visual stimuli.Biomedical optics express · 2025Article
- Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli.Science advances · 2025Article
- Dark continuous noise from visual pigment as a major mechanism underlying rod-cone difference in light sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Analysis of dim-light responses in rod and cone photoreceptors with altered calcium kinetics.Journal of mathematical biology · 2023Article
- Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.Nature communications · 2023Article
- Encoding of environmental illumination by primate melanopsin neurons.Science (New York, N.Y.) · 2023Article
- Evaluating the Talbot-Plateau law.Frontiers in neuroscience · 2023Review
- T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Predicting and Manipulating Cone Responses to Naturalistic Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Light responses of mammalian cones.Pflugers Archiv : European journal of physiology · 2021Review
- Apo-Opsin and Its Dark Constitutive Activity across Retinal Cone Subtypes.Current biology : CB · 2020Article
- Optimized Signal Flow through Photoreceptors Supports the High-Acuity Vision of Primates.Neuron · 2020Article
- Ground squirrel - A cool model for a bright vision.Seminars in cell & developmental biology · 2020Review
- A kinetic analysis of mouse rod and cone photoreceptor responses.The Journal of physiology · 2020Article
- Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior.Neuron · 2019Review
- S-cone photoreceptors in the primate retina are functionally distinct from L and M cones.eLife · 2019Article
- Light adaptation controls visual sensitivity by adjusting the speed and gain of the response to light.PloS one · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Retinal cones are photoreceptors for daylight vision. For lower vertebrates, cones are known to give monophasic, hyperpolarizing responses to light flashes. For primate cones, however, they have been reported to give strongly biphasic flash responses, with an initial hyperpolarization followed by a depolarization beyond the dark level, now a textbook dogma. We have reexamined this primate-cone observation and, surprisingly, found predominantly monophasic cone responses. Correspondingly, we found that primate cones began to adapt to steady light at much lower intensities than previously reported, explainable by a larger steady response to background light for a monophasic than for a biphasic response. Similarly, we have found a monophasic cone response for several other mammalian species. Thus, a monophasic flash response may in fact be the norm for primate and other mammalian cones as for lower-vertebrate cones. This revised information is important for ultimately understanding human retinal signal processing and correlating with psychophysical data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.