ArticleProceedings of the National Academy of Sciences of the United States of America2014
Predicting the spatiotemporal dynamics of hair follicle patterns in the developing mouse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Characterisation of human hair follicle development.Journal of anatomy · 2026Article
- Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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- Somitic positional information guides self-organized patterning of snake scales.Science advances · 2023Article
- Patterning of theFrontiers in cell and developmental biology · 2023Review
- A probabilistic Boolean model on hair follicle cell fate regulation by TGF-β.Biophysical journal · 2022Article
- Computational modeling and analysis of the morphogenetic domain signaling networks regulatingComputational and structural biotechnology journal · 2022Article
- Parallels in signaling between development and regeneration in ectodermal organs.Current topics in developmental biology · 2022Article
- Systems for intricate patterning of the vertebrate anatomy.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Article
- Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development.Developmental biology · 2021Article
- A modifier screen identifies regulators of cytoskeletal architecture as mediators of Shroom-dependent changes in tissue morphology.Biology open · 2021Article
- Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development.eLife · 2020Article
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- Article
- Article
- Hierarchical patterning modes orchestrate hair follicle morphogenesis.PLoS biology · 2017Article
- Dentin on the nanoscale: Hierarchical organization, mechanical behavior and bioinspired engineering.Dental materials : official publication of the Academy of Dental Materials · 2017Review
- Principles and mechanisms of regeneration in the mouse model for wound-induced hair follicle neogenesis.Regeneration (Oxford, England) · 2015Article
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7 authors.
Funding
Abstract
Reaction-diffusion models have been used as a paradigm for describing the de novo emergence of biological patterns such as stripes and spots. In many organisms, these initial patterns are typically refined and elaborated over the subsequent course of development. Here we study the formation of secondary hair follicle patterns in the skin of developing mouse embryos. We used the expression of sex-determining region Y box 2 to identify and distinguish the primary and secondary hair follicles and to infer the spatiotemporal dynamics of the follicle formation process. Quantitative analysis of the specific follicle patterns observed reveals a simple geometrical rule governing the formation of secondary follicles, and motivates an expansion-induction (EI) model in which new follicle formation is driven by the physical growth of the embryo. The EI model requires only one diffusible morphogen and provides quantitative, accurate predictions on the relative positions and timing of secondary follicle formation, using only the observed configuration of primary follicles as input. The same model accurately describes the positions of additional follicles that emerge from skin explants treated with an activator. Thus, the EI model provides a simple and robust mechanism for predicting secondary space-filling patterns in growing embryos.
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