ArticleProceedings of the National Academy of Sciences of the United States of America2014
Odorant receptor-mediated sperm activation in disease vector mosquitoes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 109 citations in OpenAlex.
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
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- Male-derived PBP4 is essential for sperm competition by mediating sperm motility in moths.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025Article
- The chemosensory world of mosquitoes: olfactory receptors and their role in blocking mosquito-borne disease transmission.Parasites & vectors · 2025Review
- Identification and functional verification of active volatiles recognition by the olfactory co-receptor Orco in Chrysopa pallens (Rambur) (Neuroptera: Chrysopidae).Journal of insect science (Online) · 2025Article
- Orco-dependent survival of odorant receptor neurons in ants.Science advances · 2024Article
- Odorant Receptors Expressing and Antennal Lobes Architecture Are Linked to Caste Dimorphism in Asian Honeybee,International journal of molecular sciences · 2024Article
- Elucidation of the structural basis for ligand binding and translocation in conserved insect odorant receptor co-receptors.Nature communications · 2023Article
- Mutagenesis of Odorant Receptor CoreceptorInternational journal of molecular sciences · 2023Article
- Fertility decline in female mosquitoes is regulated by theiScience · 2023Article
- Genetic mechanisms modulating behaviour through plastic chemosensory responses in insects.Molecular ecology · 2023Review
- Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera.BMC biology · 2022Article
- Genome of the hoverfly Eupeodes corollae provides insights into the evolution of predation and pollination in insects.BMC biology · 2022Article
- Discrete roles of Ir76b ionotropic coreceptor impact olfaction, blood feeding, and mating in the malaria vector mosquitoProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Identification and Characterization of Chemosensory Receptors in the Pheromone Gland-Ovipositor ofInsects · 2022Article
- Identification of Odorant-Binding and Chemosensory Protein Genes inFrontiers in physiology · 2022Article
- Ammonium transporter AcAmt mutagenesis uncovers reproductive and physiological defects without impacting olfactory responses to ammonia in the malaria vector mosquito Anopheles coluzzii.Insect biochemistry and molecular biology · 2021Article
- Trade-offs between sperm viability and immune protein expression in honey bee queens (Apis mellifera).Communications biology · 2021Article
- Gene Expression and Functional Analyses of Odorant Receptors in Small Hive Beetles (International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Insects, such as the malaria vector mosquito, Anopheles gambiae, depend upon chemoreceptors to respond to volatiles emitted from a range of environmental sources, most notably blood meal hosts and oviposition sites. A subset of peripheral signaling pathways involved in these insect chemosensory-dependent behaviors requires the activity of heteromeric odorant receptor (OR) ion channel complexes and ligands for numerous A. gambiae ORs (AgOrs) have been identified. Although AgOrs are expressed in nonhead appendages, studies characterizing potential AgOr function in nonolfactory tissues have not been conducted. In the present study, we explore the possibility that AgOrs mediate responses of spermatozoa to endogenous signaling molecules in A. gambiae. In addition to finding AgOr transcript expression in testes, we show that the OR coreceptor, AgOrco, is localized to the flagella of A. gambiae spermatozoa where Orco-specific agonists, antagonists, and other odorant ligands robustly activate flagella beating in an Orco-dependent process. We also demonstrate Orco expression and Orco-mediated activation of spermatozoa in the yellow fever mosquito, Aedes aegypti. Moreover, we find Orco localization in testes across distinct insect taxa and posit that OR-mediated responses in spermatozoa may represent a general characteristic of insect reproduction and an example of convergent evolution.
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