ArticleNucleic acids research2014
Regulation of promoter-proximal transcription elongation: enhanced DNA scrunching drives λQ antiterminator-dependent escape from a σ70-dependent pause.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Structural basis of AlpA-dependent transcription antitermination.Nucleic acids research · 2022Article
- Structural and mechanistic basis of σ-dependent transcriptional pausing.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- NusA directly interacts with antitermination factor Q from phage λ.Scientific reports · 2020Article
- Structural basis of Q-dependent antitermination.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Structural basis of Q-dependent transcription antitermination.Nature communications · 2019Article
- The Role of Pyrophosphorolysis in the Initiation-to-Elongation Transition by E. coli RNA Polymerase.Journal of molecular biology · 2019Article
- Transcription factor regulation of RNA polymerase's torque generation capacity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Reading of the non-template DNA by transcription elongation factors.Molecular microbiology · 2018Article
- Locking the nontemplate DNA to control transcription.Molecular microbiology · 2018Article
- Transcription elongation.Transcription · 2017Review
- σ38-dependent promoter-proximal pausing by bacterial RNA polymerase.Nucleic acids research · 2017Article
- A universal transcription pause sequence is an element of initiation factor σ70-dependent pausing.Nucleic acids research · 2016Article
- Two transcription pause elements underlie a σ70-dependent pause cycle.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Getting up to speed with transcription elongation by RNA polymerase II.Nature reviews. Molecular cell biology · 2015Review
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Authors and funding
2 authors.
Funding
Abstract
During initial transcription, RNA polymerase remains bound at the promoter and synthesizes RNA without movement along the DNA template, drawing downstream DNA into itself in a process called scrunching and thereby storing energy to sever the bonds that hold the enzyme at the promoter. We show that DNA scrunching also is the driving force behind the escape of RNA polymerase from a regulatory pause of the late gene operon of bacteriophage λ, and that this process is enhanced by the activity of the Q(λ) antiterminator. Furthermore, we show that failure of transcription complexes to escape the pause results in backtracking and arrest in a process analogous to abortive initiation. We identify a sequence element that modulates both abortive synthesis and the formation of arrested elongation complexes.
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Registered trials
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