ArticleHippocampus2014
Human hippocampal processing of environmental novelty during spatial navigation.
Article in Hippocampus, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- Anterior hippocampal volume predicts affect-focused psychotherapy outcome.Psychological medicine · 2020Trial
- Prior novelty invigorates future mesolimbic target detection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Toward brain-trained humanoid robots.Frontiers in neurorobotics · 2026Article
- Graded encoding of spatial novelty scales in the human brain.Nature communications · 2025Article
- Prior Novelty Invigorates Future Mesolimbic Target Detection.bioRxiv : the preprint server for biology · 2025Article
- Flexible hippocampal representation of abstract boundaries supports memory-guided choice.Nature communications · 2025Article
- Decoding Salience: A Functional Magnetic Resonance Imaging Investigation of Reward and Contextual Unexpectedness in Memory Encoding and Retrieval.Human brain mapping · 2025Article
- Investigation of Brain Regions Responsible for The Processing of The Stimulus Novelty by Using Functional Magnetic Resonance Imaging.Noro psikiyatri arsivi · 2025Article
- Frequency-specific directed connectivity between the hippocampus and parietal cortex during verbal and spatial episodic memory: an intracranial EEG replication.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Altered grid-like coding in early blind people.Nature communications · 2024Article
- Hippocampal-parietal cortex causal directed connectivity during human episodic memory formation: Replication across three experiments.bioRxiv : the preprint server for biology · 2024Article
- A different perspective on avian hippocampus function: Visual-spatial perception.Learning & behavior · 2024Article
- Translating spatial navigation evaluation from experimental to clinical settings: The virtual environments navigation assessment (VIENNA).Behavior research methods · 2024Article
- Developmental regression of novel space preference in an autism spectrum disorder model is unlinked to GABAergic and social circuitry.Frontiers in cellular neuroscience · 2024Article
- Stress disrupts insight-driven mnemonic reconfiguration in the medial temporal lobe.NeuroImage · 2023Article
- Replicable patterns of causal information flow between hippocampus and prefrontal cortex during spatial navigation and spatial-verbal memory formation.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Impact of Long-Rope Jumping on Monoamine and Attention in Young Adults.Brain sciences · 2021Article
- Ventro-dorsal Hippocampal Pathway Gates Novelty-Induced Contextual Memory Formation.Current biology : CB · 2021Article
- The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography.Brain and behavior · 2020Article
- Behavior-dependent directional tuning in the human visual-navigation network.Nature communications · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
The detection and processing of novel information encountered as we explore our environment is crucial for learning and adaptive behavior. The human hippocampus has been strongly implicated in laboratory tests of novelty detection and episodic memory, but has been less well studied during more ethological tasks such as spatial navigation, typically used in animals. We examined fMRI BOLD activity as a function of environmental and object novelty as humans performed an object-location virtual navigation task. We found greater BOLD response to novel relative to familiar environments in the hippocampus and adjacent parahippocampal gyrus. Object novelty was associated with increased activity in the posterior parahippocampal/fusiform gyrus and anterior hippocampus extending into the amygdala and superior temporal sulcus. Importantly, whilst mid-posterior hippocampus was more sensitive to environmental novelty than object novelty, the anterior hippocampus responded similarly to both forms of novelty. Amygdala activity showed an increase for novel objects that decreased linearly over the learning phase. By investigating how participants learn and use different forms of information during spatial navigation, we found that medial temporal lobe (MTL) activity reflects both the novelty of the environment and of the objects located within it. This novelty processing is likely supported by distinct, but partially overlapping, sets of regions within the MTL.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.