ArticleCerebellum (London, England)2014
Abnormalities in myelination of the superior cerebellar peduncle in patients with schizophrenia and deficits in movement sequencing.
Article in Cerebellum (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls.Schizophrenia bulletin · 2015Trial
- Consider the pons: bridging the gap on sensory prediction abnormalities in schizophrenia.Trends in neurosciences · 2022Review
- The neural substrates of neurological soft signs in schizophrenia: a systematic review.Schizophrenia (Heidelberg, Germany) · 2022Review
- Intrinsic neural network dynamics in catatonia.Human brain mapping · 2021Article
- Multimodal MRI assessment for first episode psychosis: A major change in the thalamus and an efficient stratification of a subgroup.Human brain mapping · 2021Article
- Exploring Signatures of Neurodegeneration in Early-Onset Older-Age Bipolar Disorder and Behavioral Variant Frontotemporal Dementia.Frontiers in neurology · 2021Article
- Review
- Multiparametric mapping of white matter microstructure in catatonia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Brain White Matter Correlates of Creativity in Schizophrenia: A Diffusion Tensor Imaging Study.Frontiers in neuroscience · 2020Article
- [Genuine motor phenomena in schizophrenia : Neuronal correlates and pathomechanisms].Der Nervenarzt · 2018Review
- Manual Dexterity in Schizophrenia-A Neglected Clinical Marker?Frontiers in psychiatry · 2017Article
- High-angular resolution diffusion imaging tractography of cerebellar pathways from newborns to young adults.Brain and behavior · 2017Article
- Segmentation of the Cerebellar Peduncles Using a Random Forest Classifier and a Multi-object Geometric Deformable Model: Application to Spinocerebellar Ataxia Type 6.Neuroinformatics · 2015Article
- Proceedings of the workshop on Cerebellum, Basal Ganglia and Cortical Connections Unmasked in Health and Disorder held in Brno, Czech Republic, October 17th, 2013.Cerebellum (London, England) · 2015Article
- Cerebellar-motor dysfunction in schizophrenia and psychosis-risk: the importance of regional cerebellar analysis approaches.Frontiers in psychiatry · 2014Review
- White matter differences in motor and affective-motivational networks of pain-indifferent carriers of the R221W mutation.Neurobiology of pain (Cambridge, Mass.)Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deficits in the execution of a sequence of movements are common in schizophrenia. Previous studies reported reduced functional activity in the motor cortex and cerebellum in schizophrenic patients with deficits in movement sequencing. The corticospinal tract (CST) and superior cerebellar peduncle (SCP) are fiber tracts that are involved in movement sequencing. However, the integrity of these tracts has not been evaluated in schizophrenic patients with respect to the performance of movement sequencing yet. Diffusion tensor magnetic resonance images (DT-MRI) were acquired from 24 patients with schizophrenia and 23 matched control subjects. Tractography was applied to reconstruct the CST and SCP and DT-MRI-specific parameters such as fractional anisotropy (FA) and radial diffusivity (RD) were reported. The patient group was further subdivided based on the score of sequencing of complex motor acts subscale of the Neurological Evaluation Scale into those with deficits in sequencing motor acts, the SQ(abn) group (n = 7), and those with normal performance, the SQ(norm) group (n = 17). Schizophrenia patients of the SQ(norm) subgroup had significantly reduced FA and increased RD values in the right CST in comparison to the control group; the SQ(abn) subgroup did not differ from the controls. However, the SQ(abn) subgroup showed impaired integrity of the left SCP, whereas the SQ(norm) subgroup did not. Abnormalities in the right CST in the SQ(norm) and in the left SCP in SQ(abn) groups suggest that the patients with SQ(abn) represent subgroups with distinct deficits. Moreover, these results demonstrate the involvement of the SCP in the pathogenesis of movement sequencing in schizophrenia.
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