ArticleCerebellum (London, England)2014
Developmental gene expression profile of axon guidance cues in Purkinje cells during cerebellar circuit formation.
Article in Cerebellum (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development.Frontiers in molecular neuroscience · 2023Review
- Modeling Human Cerebellar Development In Vitro in 2D Structure.Journal of visualized experiments : JoVE · 2022Article
- Article
- Cerebellar dopamine D2 receptors regulate social behaviors.Nature neuroscience · 2022Article
- Molecular mechanisms of axo-axonic innervation.Current opinion in neurobiology · 2021Review
- An Extracellular Perspective on CNS Maturation: Perineuronal Nets and the Control of Plasticity.International journal of molecular sciences · 2021Review
- Deficiency of TRIM32 Impairs Motor Function and Purkinje Cells in Mid-Aged Mice.Frontiers in aging neuroscience · 2021Article
- Eph/ephrin Function Contributes to the Patterning of Spinocerebellar Mossy Fibers Into Parasagittal Zones.Frontiers in systems neuroscience · 2020Article
- Neuropilin-1-mediated pruning of corticospinal tract fibers is required for motor recovery after spinal cord injury.Cell death & disease · 2019Article
- Tubulin-related cerebellar dysplasia: definition of a distinct pattern of cerebellar malformation.European radiology · 2017Article
- NRP1 and synapse formation.Oncotarget · 2016Article
- Article
- Toll-Like Receptor 4 Deficiency Impairs Motor Coordination.Frontiers in neuroscience · 2016Article
- The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients.Schizophrenia research · 2015Article
- Twitch-related and rhythmic activation of the developing cerebellar cortex.Journal of neurophysiology · 2015Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The establishment of precise neural circuits during development involves a variety of contact-mediated and secreted guidance molecules that are expressed in a complementary fashion by different cell types. To build a functional circuit, each cell type must first trigger an intrinsic genetic program that is led by their environment at a key time point. It is therefore essential to identify the different cell-specific and stage-specific transcriptional profiles expressed by neurons. However, very few studies have been done to address this issue thus far. Herein, we have carried out a large-scale quantitative real-time PCR analysis of all classical axon guidance molecules (i.e., Semaphorins, Netrins, Ephrins, and Slits) and their receptors expressed by Purkinje cells (PCs) at specific stages of postnatal cerebellar development in vivo. Most cerebellar connections are setup in a well-characterized sequential manner during postnatal development and lead to the fine regulation of the PC, the sole output of the structure. Our analysis of the relative expression of these guidance cues has uncovered a dynamic expression pattern corresponding to specific stages of cerebellar development, thus providing a starting point for studying the role of these axon guidance molecules in cerebellar wiring.
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