ArticleDevelopment (Cambridge, England)2014
Embryonic bauplans and the developmental origins of facial diversity and constraint.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- Navigating the window: structural bottlenecks in avian craniofacial integration revealed by the ontogenetic patterning of shape variance.bioRxiv : the preprint server for biology · 2026Article
- Comparative analysis of morphological atlas at different HH stages of embryonic development for SPF ducks and SPF chickens.Poultry science · 2026Article
- Epiblast lumenogenesis is not a mammalian-specific trait.Nature communications · 2026Article
- Structural Equation Modeling Reveals How Allometry Shapes Integration in Avian Cranial Evolution.Integrative and comparative biology · 2026Article
- Anatomy-aware, label-informed approach improves image registration for challenging datasets.PloS one · 2026Article
- Comparative study of fetal facial shape between Japanese and North American populations using micro-CT.Scientific reports · 2025Article
- Positional programs in early murine facial development and their role in human facial shape variability.Nature communications · 2025Article
- Article
- Palatal segment contributions to midfacial anterior-posterior growth.Journal of anatomy · 2025Article
- The Evolution of Skull Shape in Boana faber Clade: Unraveling Heterochrony's Influence.Evolution & development · 2025Article
- Article
- Sonic hedgehog and fibroblast growth factor 8 regulate the evolution of amniote facial proportions.Communications biology · 2025Article
- From neural crest migration to the onset of gangliogenesis.Current topics in developmental biology · 2025Review
- Palatal segment contributions to midfacial anterior-posterior growth.bioRxiv : the preprint server for biology · 2024Article
- Cellular, Molecular, and Genetic Mechanisms of Avian Beak Development and Evolution.Annual review of genetics · 2024Review
- Dynamic evolutionary interplay between ontogenetic skull patterning and whole-head integration.Nature ecology & evolution · 2024Article
- A deep learning approach for morphological feature extraction based on variational auto-encoder: an application to mandible shape.NPJ systems biology and applications · 2023Article
- Developmental origin underlies evolutionary rate variation across the placental skull.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Article
- Early shape divergence of developmental trajectories in the jaw of galeomorph sharks.Frontiers in zoology · 2022Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
A central issue in biology concerns the presence, timing and nature of phylotypic periods of development, but whether, when and why species exhibit conserved morphologies remains unresolved. Here, we construct a developmental morphospace to show that amniote faces share a period of reduced shape variance and convergent growth trajectories from prominence formation through fusion, after which phenotypic diversity sharply increases. We predict in silico the phenotypic outcomes of unoccupied morphospaces and experimentally validate in vivo that observed convergence is not due to developmental limits on variation but instead from selection against novel trajectories that result in maladaptive facial clefts. These results illustrate how epigenetic factors such as organismal geometry and shape impact facial morphogenesis and alter the locus of adaptive selection to variation in later developmental events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.