ArticleObesity (Silver Spring, Md.)2014
Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity.
Article in Obesity (Silver Spring, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed, 187 citations in OpenAlex.
- Does exercise during a ketogenic diet effectively alter appetite sensation, appetite-regulating hormones, and body composition?Experimental biology and medicine (Maywood, N.J.) · 2022Trial
- Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models.Experimental physiology · 2026Article
- Biochemical, Immunohistochemical and Behavioral Effects of Spexin in a Methimazole-Induced Hypothyroidism Rat Model.Biology · 2026Article
- Peptide hormone spexin restores beta cell function and improves glycaemic control in mice via regulation of the sodium-potassium pump.Diabetologia · 2026Article
- Nephroprotective effect of spexin in dogs and cats.BMC veterinary research · 2026Article
- Metabolic, adipokine (irisin, spexin, visfatin), and ER stress (GRP78) responses in multiparous Brown Swiss cows: a multivariate approach across physiological stages and body condition scores.Archives animal breeding · 2026Article
- Emerging roles of spexin in cardiovascular homeostasis.Frontiers in cardiovascular medicine · 2026Review
- Serum spexin levels in women with diminished ovarian reserve: a prospective case-control study.Frontiers in medicine · 2026Article
- Association between serum spexin levels and diabetic nephropathy in patients with type 2 diabetes: a cross-sectional study.International urology and nephrology · 2025Article
- Associations Between Circulating Spexin, Obesity, and Insulin Resistance in Korean Children and Adolescents.Nutrients · 2025Article
- Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy.Cardiovascular diabetology · 2025Review
- Involvement of central opioid and melanocortin receptors in spexin-induced hypophagia following intracerebroventricular injection in neonatal broiler chicks.BMC veterinary research · 2025Article
- Spexin Adipokinin and TRPM2 ION Channel in Lung Cancer Use as a Bıomarker in Hıstopathologic Diagnosis.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- The relationship between spexin and liver steatosis in polycystic ovary syndrome: a novel analysis using ultrasound-guided attenuation parameter.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Hydroxytyrosol has a protective effect on the kidneys through dardarin and spexin.Northern clinics of Istanbul · 2025Article
- Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway.Nutrition & metabolism · 2024Article
- Role of Spexin in White Adipose Tissue Thermogenesis under Basal and Cold-Stimulated Conditions.International journal of molecular sciences · 2024Article
- Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin.Iranian journal of basic medical sciences · 2024Article
- Huangqin-Huanglian Decoction Protects Liver against Non-alcoholic Fatty Liver Disease in High Fat-diet Mice.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction.Advances in experimental medicine and biology · 2024Review
28 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveMicroarray studies identified Ch12:orf39 (Spexin) as the most down-regulated gene in obese human fat. Therefore, we examined its role in obesity pathogenesis.
methodsSpexin effects on food intake, meal patterns, body weight, respiratory exchange ratio (RER), and locomotor activity were monitored electronically in C57BL/6J mice or Wistar rats with diet-induced obesity (DIO). Its effects on adipocyte [(3)H]-oleate uptake were determined.
resultsIn humans, Spexin gene expression was down-regulated 14.9-fold in obese omental and subcutaneous fat. Circulating Spexin changed in parallel, correlating (r = -0.797) with Leptin. In rats, Spexin (35 µg/kg/day SC) reduced caloric intake ∼32% with corresponding weight loss. Meal patterns were unaffected. In mice, Spexin (25 µg/kg/day IP) significantly reduced the RER at night, and increased locomotion. Spexin incubation in vitro significantly inhibited facilitated fatty acid (FA) uptake into DIO mouse adipocytes. Conditioned taste aversion testing (70 µg/kg/day IP) demonstrated no aversive Spexin effects.
conclusionsSpexin gene expression is markedly down-regulated in obese human fat. The peptide produces weight loss in DIO rodents. Its effects on appetite and energy regulation are presumably central; those on adipocyte FA uptake appear direct and peripheral. Spexin is a novel hormone involved in weight regulation, with potential for obesity therapy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.