Evidence map›Paper›PMID 24550057›Full record

ArticleThorax2014

Cell migration leads to spatially distinct but clonally related airway cancer precursors.

Christodoulos P Pipinikas, Theodoros S Kiropoulos, Vitor H Teixeira, James M Brown, Aikaterini Varanou, Mary Falzon, Arrigo Capitanio, Steven E Bottoms, Bernadette Carroll, Neal Navani and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  12. Review
  13. Evolution of Premalignant Disease.Cold Spring Harbor perspectives in medicine · 2017
    Review
  14. Article
  15. Article
  16. Epithelial cell migration as a potential therapeutic target in early lung cancer.European respiratory review : an official journal of the European Respiratory Society · 2017
    Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Christodoulos P PipinikasLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
Theodoros S KiropoulosLungs for Living Research Centre, UCL Respiratory, University College London, London, UK Department of Respiratory Medicine, University of Thessaly School of Medicine, Larissa, Greece.
Vitor H TeixeiraLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
James M BrownLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
Aikaterini VaranouLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
Mary FalzonDepartment of Pathology, University College London, London, UK.
Arrigo CapitanioDepartment of Pathology, University College London, London, UK.
Steven E BottomsLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
Bernadette CarrollDepartment of Thoracic Medicine, University College London Hospital, London, UK.
Neal NavaniLungs for Living Research Centre, UCL Respiratory, University College London, London, UK Department of Thoracic Medicine, University College London Hospital, London, UK.
Frank McCaughanDepartment of Biochemistry, University of Cambridge, Cambridge, UK Department of Asthma, Allergy and Respiratory Science, King's College London, London, UK.
Jeremy P GeorgeDepartment of Thoracic Medicine, University College London Hospital, London, UK.
Adam GiangrecoLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
Nicholas A WrightHistopathology Laboratory, Cancer Research UK London Research Institute, London, UK Centre for Digestive Diseases, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Stuart A C McDonaldHistopathology Laboratory, Cancer Research UK London Research Institute, London, UK Centre for Digestive Diseases, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Trevor A GrahamHistopathology Laboratory, Cancer Research UK London Research Institute, London, UK Centre for Evolution and Cancer, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA.
Sam M JanesLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
University College London · GBQueen Mary University of London · GBCancer Research UK · GBUniversity of Cambridge · GBUniversity of Thessaly · GR

Funding

Cancer Research UK 14895Department of HealthMedical Research Council G0500392Wellcome Trust 091730
6 · The paper itself

Abstract

backgroundSquamous cell carcinoma of the lung is a common cancer with 95% mortality at 5 years. These cancers arise from preinvasive lesions, which have a natural history of development progressing through increasing severity of dysplasia to carcinoma in situ (CIS), and in some cases, ending in transformation to invasive carcinoma. Synchronous preinvasive lesions identified at autopsy have been previously shown to be clonally related.

methodsUsing autofluorescence bronchoscopy that allows visual observation of preinvasive lesions within the upper airways, together with molecular profiling of biopsies using gene sequencing and loss-of-heterozygosity analysis from both preinvasive lesions and from intervening normal tissue, we have monitored individual lesions longitudinally and documented their visual, histological and molecular relationship.

resultsWe demonstrate that rather than forming a contiguous field of abnormal tissue, clonal CIS lesions can develop at multiple anatomically discrete sites over time. Further, we demonstrate that patients with CIS in the trachea have invariably had previous lesions that have migrated proximally, and in one case, into the other lung over a period of 12 years.

conclusionsMolecular information from these unique biopsies provides for the first time evidence that field cancerisation of the upper airways can occur through cell migration rather than via local contiguous cellular expansion as previously thought. Our findings urge a clinical strategy of ablating high-grade premalignant airway lesions with subsequent attentive surveillance for recurrence in the bronchial tree.

Indexed as

Carcinoma in SituCarcinoma, Squamous CellCell MovementLung NeoplasmsMutationPrecancerous ConditionsTracheal NeoplasmsAdultGenes, p53HumansLoss of HeterozygosityMaleMiddle AgedNeoplasm InvasivenessAirway EpitheliumLung Cancer

Identifiers

PMID24550057
PMCPMC4033139
OpenAlexW2171993363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.