ArticleMethods in molecular biology (Clifton, N.J.)2014
Introduction to cotranscriptional RNA splicing.
Article in Methods in molecular biology (Clifton, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Co-transcriptional splicing facilitates transcription of gigantic genes.PLoS genetics · 2024Article
- The Role of mRNA Alternative Splicing in Macrophages Infected withMolecules (Basel, Switzerland) · 2024Review
- A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy.Molecular cell · 2023Article
- Combining genetic constraint with predictions of alternative splicing to prioritize deleterious splicing in rare disease studies.BMC bioinformatics · 2022Article
- Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4.Brain : a journal of neurology · 2022Article
- Conditional depletion of transcriptional kinases Ctk1 and Bur1 and effects on co-transcriptional spliceosome assembly and pre-mRNA splicing.RNA biology · 2021Article
- Nuclear compartmentalization as a mechanism of quantitative control of gene expression.Nature reviews. Molecular cell biology · 2021Review
- Review
- Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization.Developmental cell · 2021Article
- Review
- Covering all your bases: incorporating intron signal from RNA-seq data.NAR genomics and bioinformatics · 2020Article
- ADAR-deficiency perturbs the global splicing landscape in mouse tissues.Genome research · 2020Article
- Post-transcriptional splicing of nascent RNA contributes to widespread intron retention in plants.Nature plants · 2020Article
- HIV-1 spliced RNAs display transcription start site bias.RNA (New York, N.Y.) · 2020Article
- An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement.Molecular therapy. Nucleic acids · 2020Article
- Nascent RNA analyses: tracking transcription and its regulation.Nature reviews. Genetics · 2019Review
- Spt5 modulates cotranscriptional spliceosome assembly inRNA (New York, N.Y.) · 2019Article
- Viral modulation of cellular RNA alternative splicing: A new key player in virus-host interactions?Wiley interdisciplinary reviews. RNA · 2019Review
- Alternative Splicing and Protein Diversity: Plants Versus Animals.Frontiers in plant science · 2019Review
- Mathematical modeling identifies potential gene structure determinants of co-transcriptional control of alternative pre-mRNA splicing.Nucleic acids research · 2018Article
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3 authors.
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Abstract
The discovery that many intron-containing genes can be cotranscriptionally spliced has led to an increased understanding of how splicing and transcription are intricately intertwined. Cotranscriptional splicing has been demonstrated in a number of different organisms and has been shown to play roles in coordinating both constitutive and alternative splicing. The nature of cotranscriptional splicing suggests that changes in transcription can dramatically affect splicing, and new evidence suggests that splicing can, in turn, influence transcription. In this chapter, we discuss the mechanisms and consequences of cotranscriptional splicing and introduce some of the tools used to measure this process.
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