ArticleThe Journal of cell biology1988
Distribution and lateral mobility of voltage-dependent sodium channels in neurons.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Neurotoxin-Derived Optical Probes for Biological and Medical Imaging.Molecular imaging and biology · 2023Review
- Inferences from FRAP data are model dependent: A subdiffusive analysis.Biophysical journal · 2022Article
- A sticky situation: regulation and function of protein palmitoylation with a spotlight on the axon and axon initial segment.Neuronal signaling · 2021Review
- Functional interactions of ion channels with the actin cytoskeleton: does coupling to dynamic actin regulate NMDA receptors?The Journal of physiology · 2021Review
- The Axon Initial Segment: An Updated Viewpoint.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Influence of Membrane Receptor Lateral Diffusion on the Short-Term Depression of Acetylcholine-Induced Current in Helix Neurons.Cellular and molecular neurobiology · 2017Article
- Surface dynamics of voltage-gated ion channels.Channels (Austin, Tex.) · 2016Review
- Interfacing Cultured Neurons to Microtransducers Arrays: A Review of the Neuro-Electronic Junction Models.Frontiers in neuroscience · 2016Review
- Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment.Journal of computational neuroscience · 2015Article
- Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons.Molecular brain · 2014Article
- Parameter importance in FRAP acquisition and analysis: a simulation approach.Biophysical journal · 2013Article
- Simplified equation to extract diffusion coefficients from confocal FRAP data.Traffic (Copenhagen, Denmark) · 2012Article
- Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons.Molecular brain · 2011Article
- Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier.The Journal of cell biology · 2010Article
- Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.The Journal of biological chemistry · 2010Article
- Persistent sodium current in layer 5 neocortical neurons is primarily generated in the proximal axon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Derivation of a closed form analytical expression for fluorescence recovery after photo bleaching in the case of continuous bleaching during read out.The European physical journal. E, Soft matter · 2005Article
- Voltage-gated sodium channels and ankyrinG occupy a different postsynaptic domain from acetylcholine receptors from an early stage of neuromuscular junction maturation in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Excitability of the soma in central nervous system neurons.Biophysical journal · 2000Article
- Axonal expression of sodium channels in rat spinal neurones during postnatal development.The Journal of physiology · 1999Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Voltage-dependent sodium channels are distributed nonuniformly over the surface of nerve cells and are localized to morphologically distinct regions. Fluorescent neurotoxin probes specific for the voltage-dependent sodium channel stain the axon hillock 5-10 times more intensely than the cell body and show punctate fluorescence confined to the axon hillock which can be compared with the more diffuse and uniform labeling in the cell body. Using fluorescence photobleaching recovery (FPR) we measured the lateral mobility of voltage-dependent sodium channels over specific regions of the neuron. Nearly all sodium channels labeled with specific neurotoxins are free to diffuse within the cell body with lateral diffusion coefficients on the order of 10(-9) cm2/s. In contrast, lateral diffusion of sodium channels in the axon hillock is restricted, apparently in two different ways. Not only do sodium channels in these regions diffuse more slowly (10(-10)-10(-11) cm2/s), but also they are prevented from diffusing between axon hillock and cell body. No regionalization or differential mobilities were observed, however, for either tetramethylrhodamine-phosphatidylethanolamine, a probe of lipid diffusion, or FITC-succinyl concanavalin A, a probe for glycoproteins. During the maturation of the neuron, the plasma membrane differentiates and segregates voltage-dependent sodium channels into local compartments and maintains this localization perhaps either by direct cytoskeletal attachments or by a selective barrier to channel diffusion.
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