ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Andexanet alfa Reduces Hematoma Expansion Following Controlled Cortical Impact in Mice Pretreated with Rivaroxaban.Neurocritical care · 2026Article
- Brain Atrophy Is Associated with Hematoma Expansion in Intracerebral Hemorrhage, Depending on Coagulation Status.Journal of clinical medicine · 2025Article
- Mechanism of exacerbation of traumatic brain injury under warfarin anticoagulation in male mice.PloS one · 2024Article
- Induction of endothelial barrier dysfunction by serum factors in rats subjected to traumatic brain injury and hemorrhagic shock.Physiological reports · 2022Article
- Article
- Intracranial hemorrhage in anticoagulated patients with mild traumatic brain injury: significant differences between direct oral anticoagulants and vitamin K antagonists.Internal and emergency medicine · 2018Observational
- Prevalence of Intracranial Hemorrhage after Blunt Head Trauma in Patients on Pre-injury Dabigatran.The western journal of emergency medicine · 2017Observational
- Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2017Article
- Traumatic fatal cerebral hemorrhage in an old patient with a history of multiple sclerosis under dabigatran: a case report and review of the literature.Journal of geriatric cardiology : JGC · 2015Article
- Reversal of anticoagulant effects in patients with intracerebral hemorrhage.Current neurology and neuroscience reports · 2015Review
- Intracranial hemorrhage mortality in atrial fibrillation patients treated with dabigatran or warfarin.Stroke · 2014Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
To date, only limited data are available on the effects of pretreatment with novel oral anticoagulants in the event of traumatic brain injury (TBI). We determined intracerebral hemorrhage volume and functional outcome in a standardized TBI model in mice treated with warfarin or dabigatran. Additionally, we investigated whether excess concentrations of dabigatran could increase bleeding and whether this was preventable by using prothrombin complex concentrate (PCC). C57 mice were treated orally with warfarin or dabigatran; sham-treated mice served as controls. Effective anticoagulation was verified by measurement of international normalized ratio and diluted thrombin time, and TBI was induced by controlled cortical impact (CCI). Twenty-four hours after CCI, intracerebral hemorrhage volume was larger in warfarin-pretreated mice than in controls (10.1 ± 4.9 vs 4.1 ± 1.7 μL; analysis of variance post hoc P=0.001), but no difference was found between controls and dabigatran-pretreated mice (5.3 ± 1.5 μL). PCC applied 30 minutes after CCI did not reliably reduce intracerebral hemorrhage induced by excess dabigatran concentration compared with saline (10.4 ± 11.2 vs 8.7 ± 7.1 μL). Our data suggest pathophysiological differences in TBI occurring during warfarin and dabigatran anticoagulation. The reduced hemorrhage formation under dabigatran therapy could present a safety advantage compared with warfarin. An excess dabigatran concentration, however, can increase hemorrhage.
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