ArticlePrion
Classifying prion and prion-like phenomena.
Article in Prion. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Optimizing strategy for the discovery of compositionally-biased or low-complexity regions in proteins.Scientific reports · 2024Article
- How Big Is the Yeast Prion Universe?International journal of molecular sciences · 2023Review
- Evolution of sequence traits of prion-like proteins linked to amyotrophic lateral sclerosis (ALS).PeerJ · 2022Article
- Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases?Biomolecules · 2021Review
- Alzheimer's Disease: From Pathogenesis to Mesenchymal Stem Cell Therapy - Bridging the Missing Link.Frontiers in cellular neuroscience · 2021Review
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- Prions: Roles in Development and Adaptive Evolution.Journal of molecular evolution · 2020Review
- Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.International journal of molecular sciences · 2020Review
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- Prionoid Proteins in the Pathogenesis of Neurodegenerative Diseases.Frontiers in molecular neuroscience · 2019Review
- Evolutionary behaviour of bacterial prion-like proteins.PloS one · 2019Article
- The Prion 2018 round tables (II): Aβ, tau, α-synuclein… are they prions, prion-like proteins, or what?Prion · 2019Article
- Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges.Journal of Alzheimer's disease : JAD · 2019Review
- fLPS: Fast discovery of compositional biases for the protein universe.BMC bioinformatics · 2017Article
- The cellular prion protein (PrPPrion · 2017Article
- The evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans.Biology direct · 2016Article
- Emergence and evolution of yeast prion and prion-like proteins.BMC evolutionary biology · 2016Article
- Interaction networks of prion, prionogenic and prion-like proteins in budding yeast, and their role in gene regulation.PloS one · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The universe of prion and prion-like phenomena has expanded significantly in the past several years. Here, we overview the challenges in classifying this data informatically, given that terms such as "prion-like", "prion-related" or "prion-forming" do not have a stable meaning in the scientific literature. We examine the spectrum of proteins that have been described in the literature as forming prions, and discuss how "prion" can have a range of meaning, with a strict definition being for demonstration of infection with in vitro-derived recombinant prions. We suggest that although prion/prion-like phenomena can largely be apportioned into a small number of broad groups dependent on the type of transmissibility evidence for them, as new phenomena are discovered in the coming years, a detailed ontological approach might be necessary that allows for subtle definition of different "flavors" of prion / prion-like phenomena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.