Self-gratification yields not-so-naive T cells.

Christopher E Martin, Charles D Surh

Abstract readComment

In one paragraph

Article in Nature immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Naïve helper T cells with high CD5 expression have increased calcium signaling.PloS one · 2017
Article

4 · The record

Corrections and comments

Comment on
Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC.2014

5 · Who and what money

Authors and funding

2 authors.

Christopher E MartinDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA, and the Kellogg School of Science and Technology Doctoral Program in Chemical and Biological Sciences, The Scripps Research Institute, La Jolla, California, USA.

Charles D SurhAcademy of Immunology and Microbiology, Institute for Basic Science, Pohang, Republic of Korea, the Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA, and the Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAutoantigensCD4-Positive T-LymphocytesHumansLymphocyte ActivationMajor Histocompatibility ComplexReceptors, Antigen, T-CellAutoantigensReceptors, Antigen, T-Cell

Identifiers

PMID24549065

DOI10.1038/ni.2832

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.