ArticleEuropean journal of human genetics : EJHG2014
Using ancestry-informative markers to identify fine structure across 15 populations of European origin.
Article in European journal of human genetics : EJHG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A common variant in the CLDN7/ELP5 locus predicts adiponectin change with lifestyle intervention and improved fitness in obese individuals with diabetes.Physiological genomics · 2015Trial
- Regional European genetic ancestry predicts type I interferon level and risk of severe viral infection.QJM : monthly journal of the Association of Physicians · 2024Article
- Genotypes of informative loci from 1000 Genomes data allude evolution and mixing of human populations.Scientific reports · 2021Article
- Fine scale human genetic structure in three regions of Cameroon reveals episodic diversifying selection.Scientific reports · 2021Article
- Developing ancestry informative marker panel for Nigeria- Cameroonian chimpanzees.Journal of genetics · 2020Article
- Ancestry-informative marker (AIM) SNP panel for the Malay population.International journal of legal medicine · 2020Article
- Using Ancestry Informative Markers (AIMs) to Detect Fine Structures Within Gorilla Populations.Frontiers in genetics · 2019Article
- Ancient Ancestry Informative Markers for Identifying Fine-Scale Ancient Population Structure in Eurasians.Genes · 2018Article
- Article
- Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners.International archives of occupational and environmental health · 2018Article
- Genetically decreased vitamin D and risk of Alzheimer disease.Neurology · 2016Article
- Obesity and Multiple Sclerosis: A Mendelian Randomization Study.PLoS medicine · 2016Article
- Tracking crop varieties using genotyping-by-sequencing markers: a case study using cassava (Manihot esculenta Crantz).BMC genetics · 2015Article
- A genome-wide association study of anorexia nervosa.Molecular psychiatry · 2014Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The Wellcome Trust Case Control Consortium 3 anorexia nervosa genome-wide association scan includes 2907 cases from 15 different populations of European origin genotyped on the Illumina 670K chip. We compared methods for identifying population stratification, and suggest list of markers that may help to counter this problem. It is usual to identify population structure in such studies using only common variants with minor allele frequency (MAF) >5%; we find that this may result in highly informative SNPs being discarded, and suggest that instead all SNPs with MAF >1% may be used. We established informative axes of variation identified via principal component analysis and highlight important features of the genetic structure of diverse European-descent populations, some studied for the first time at this scale. Finally, we investigated the substructure within each of these 15 populations and identified SNPs that help capture hidden stratification. This work can provide information regarding the designing and interpretation of association results in the International Consortia.
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