Evidence map›Paper›PMID 24549027›Full record

Trial reportEuropean journal of clinical nutrition2014

Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study.

O K Magnusdottir, R Landberg, I Gunnarsdottir, L Cloetens, B Akesson, M Landin-Olsson, F Rosqvist, D Iggman, U Schwab, K-H Herzig and 8 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 4 countries.

O K Magnusdottir1] Unit for Nutrition Research, Landspitali-The National University Hospital of Iceland, Reykjavík, Iceland [2] Faculty of Food Science and Nutrition and School of Health Sciences, University of Iceland, Reykjavík, Iceland.
R Landberg1] Department of Food Science, BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden [2] Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
I Gunnarsdottir1] Unit for Nutrition Research, Landspitali-The National University Hospital of Iceland, Reykjavík, Iceland [2] Faculty of Food Science and Nutrition and School of Health Sciences, University of Iceland, Reykjavík, Iceland.
L CloetensBiomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden.
B Akesson1] Biomedical Nutrition, Pure and Applied Biochemistry, Lund University, Lund, Sweden [2] Department of Clinical Nutrition, Skåne University Hospital, Lund, Sweden.
M Landin-OlssonDepartment of Endocrinology, Skåne University Hospital, Lund, Sweden.
F RosqvistDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
D Iggman1] Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden [2] Center for Clinical Research Dalarna, Falun, Sweden.
U Schwab1] Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland [2] Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland.
K-H Herzig1] Department of Physiology and Biocenter of Oulu, Institute of Biomedicine, Oulu University, Oulu, Finland [2] Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland.
M J Savolainen1] Department of Internal Medicine and Biocenter Oulu, Institute of Clinical Medicine, University of Oulu, Oulu, Finland [2] Clinical Research Center, Oulu University Hospital, Oulu, Finland.
L BraderDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
K HermansenDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
M Kolehmainen1] Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland [2] VTT, Technical Research Centre of Finland, Espoo and Kuopio, Kuopio, Finland.
K Poutanen1] Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland [2] VTT, Technical Research Centre of Finland, Espoo and Kuopio, Kuopio, Finland.
M Uusitupa1] Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland [2] Research Unit, Kuopio University Hospital, Kuopio, Finland.
I Thorsdottir1] Unit for Nutrition Research, Landspitali-The National University Hospital of Iceland, Reykjavík, Iceland [2] Faculty of Food Science and Nutrition and School of Health Sciences, University of Iceland, Reykjavík, Iceland.
U RisérusDepartment of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
University of Eastern Finland · FILund University · SEAarhus University Hospital · DKUniversity of Iceland · ISUppsala University · SECenter for Clinical Research Dalarna · SENational University Hospital of Iceland · ISOulu University Hospital · FISwedish University of Agricultural Sciences · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesFew studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS). SUBJECTS/

methodsParticipants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.

resultsND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.

conclusionsThe AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS.

Indexed as

Insulin ResistanceSecaleAdultAgedBiomarkersBlood GlucoseBody Mass IndexDietary FiberHealthy VolunteersHumansInsulinLinear ModelsMetabolic SyndromeMiddle AgedResorcinolsTriticumBiomarkersBlood GlucoseDietary FiberInsulinResorcinols

Identifiers

PMID24549027
OpenAlexW2013652987

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.