ArticleTranslational psychiatry2014
Polygenic determinants of white matter volume derived from GWAS lack reproducibility in a replicate sample.
Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project.Translational psychiatry · 2023Article
- Structural neuroimaging phenotypes and associated molecular and genomic underpinnings in autism: a review.Frontiers in neuroscience · 2023Review
- Do we measure or compute polygenic risk scores? Why language matters.Human genetics · 2022Article
- Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype-Based Approach.Schizophrenia bulletin · 2019Article
- OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.Molecular psychiatry · 2018Article
- A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- Associations between polygenic risk scores for four psychiatric illnesses and brain structure using multivariate pattern recognition.NeuroImage. Clinical · 2018Article
- Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations.Schizophrenia bulletin · 2017Article
- Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank.Scientific reports · 2017Article
- Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis.Translational psychiatry · 2016Article
- Limited Evidence for Association of Genome-Wide Schizophrenia Risk Variants on Cortical Neuroimaging Phenotypes.Schizophrenia bulletin · 2016Article
- Associations between polygenic risk for schizophrenia and brain function during probabilistic learning in healthy individuals.Human brain mapping · 2016Article
- Schizophrenia risk variants modulate white matter volume across the psychosis spectrum: evidence from two independent cohorts.NeuroImage. Clinical · 2015Article
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Authors and funding
9 authors.
Funding
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Abstract
A recent publication reported an exciting polygenic effect of schizophrenia (SCZ) risk variants, identified by a large genome-wide association study (GWAS), on total brain and white matter volumes in schizophrenic patients and, even more prominently, in healthy subjects. The aim of the present work was to replicate and then potentially extend these findings. According to the original publication, polygenic risk scores-using single nucleotide polymorphism (SNP) information of SCZ GWAS-(polygenic SCZ risk scores; PSS) were calculated in 122 healthy subjects, enrolled in a structural magnetic resonance imaging (MRI) study. These scores were computed based on P-values and odds ratios available through the Psychiatric GWAS Consortium. In addition, polygenic white matter scores (PWM) were calculated, using the respective SNP subset in the original publication. None of the polygenic scores, either PSS or PWM, were found to be associated with total brain, white matter or gray matter volume in our replicate sample. Minor differences between the original and the present study that might have contributed to lack of reproducibility (but unlikely explain it fully), are number of subjects, ethnicity, age distribution, array technology, SNP imputation quality and MRI scanner type. In contrast to the original publication, our results do not reveal the slightest signal of association of the described sets of GWAS-identified SCZ risk variants with brain volumes in adults. Caution is indicated in interpreting studies building on polygenic risk scores without replication sample.
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