Evidence map›Paper›PMID 24548865›Full record

ArticleBritish journal of cancer2014

Reproductive risk factors and oestrogen/progesterone receptor-negative breast cancer in the Breast Cancer Family Registry.

M E Work, E M John, I L Andrulis, J A Knight, Y Liao, A M Mulligan, M C Southey, G G Giles, G S Dite, C Apicella and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Breastfeeding and breast cancer risk by receptor status--a systematic review and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2015
    Pooled it
  4. Article
  5. Review
  6. Pregnancy associated breast cancer: correlation between parity and ultrasonic characteristics of tumors & background echotexture.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Gestational diabetes and risk of breast cancer before age 55 years.International journal of epidemiology · 2022
    Article
  17. A Validated Risk Prediction Model for Breast Cancer in US Black Women.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

M E WorkDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA.
E M John1] Cancer Prevention Institute of California, Fremont, CA 94538, USA [2] Division of Epidemiology, Department of Health Research and Policy, and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305-5101, USA.
I L AndrulisDepartment of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5.
J A Knight1] Department of Molecular Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5 [2] Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada M5T 3M7.
Y LiaoDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA.
A M Mulligan1] Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada M5G 1X5 [2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5G 1X5.
M C SoutheyDepartment of Pathology, The University of Melbourne, Melbourne, VIC 3010, Australia.
G G Giles1] Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, VIC 3053, Australia [2] Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC 3010, Australia.
G S DiteCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC 3010, Australia.
C ApicellaCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC 3010, Australia.
H HibshooshDepartment of Epidemiology and Institute of Health and Environment, School of Public Health, Seoul National University, 110-799 Seoul, Korea.
J L Hopper1] Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC 3010, Australia [2] Department of Epidemiology and Institute of Health and Environment, School of Public Health, Seoul National University, 110-799 Seoul, Korea.
M B Terry1] Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA [2] Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.
University of Melbourne · AUColumbia University · USCancer Council Victoria · AUCancer Prevention Institute of California · USColumbia University Irving Medical Center · USLunenfeld-Tanenbaum Research Institute · CASeoul National University · KRUniversity Health Network · CAUniversity of Toronto · CA

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
ONTARIO REGISTRY FOR STUDIES OF FAMILIAL BREAST CANCERU01CA069467 · NCI · CANCER CARE ONTARIO · PI ANDRULIS, IRENE L. · 1995 to 2010
$10.4M
THE AUSTRALIAN BREAST CANCER FAMILY REGISTRYU01CA069638 · NCI · UNIVERSITY OF MELBOURNE · PI HOPPER, JOHN L · 1995 to 2010
$6.6M
CANCER EPIDEMIOLOGY/BIOSTATISTICS/ENVIRONMENTAL SCIENCEST32CA009529 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI NEUGUT, ALFRED I. · 1985 to 2012
$4.3M
CLINICAL AND TRANSLATIONAL SCIENCE AWARDTL1RR024158 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$1.6M
GENETIC EPIDEMIOLOGY OF OVARIAN CANCERU01CA071966 · NCI · STANFORD UNIVERSITY · PI WHITTEMORE, ALICE S · 1996 to 2002
$1.2M
NCATS NIH HHS TL1 TR00008NCI NIH HHS RFA-CA-06-503NCI NIH HHS T32 CA009529NCI NIH HHS U01 CA069467NCI NIH HHS U01 CA069638NCI NIH HHS U01 CA694117NCI NIH HHS U01 CA69467NCI NIH HHS U01 CA69638NCI NIH HHS U01CA 71966NCI NIH HHS UM1 CA164920NCRR NIH HHS TL1 RR024158NIEHS NIH HHS P30 ES009089
6 · The paper itself

Abstract

backgroundOestrogen receptor (ER)- and progesterone receptor (PR)-negative (ER-PR-) breast cancer is associated with poorer prognosis compared with other breast cancer subtypes. High parity has been associated with an increased risk of ER-PR- cancer, but emerging evidence suggests that breastfeeding may reduce this risk. Whether this potential breastfeeding benefit extends to women at high risk of breast cancer remains critical to understand for prevention.

methodsUsing population-based ascertained cases (n=4011) and controls (2997) from the Breast Cancer Family Registry, we examined reproductive risk factors in relation to ER and PR status.

resultsHigh parity (≥3 live births) without breastfeeding was positively associated only with ER-PR- tumours (odds ratio (OR)=1.57, 95% confidence interval (CI), 1.10-2.24); there was no association with parity in women who breastfed (OR=0.93, 95% CI 0.71-1.22). Across all race/ethnicities, associations for ER-PR- cancer were higher among women who did not breastfeed than among women who did. Oral contraceptive (OC) use before 1975 was associated with an increased risk of ER-PR- cancer only (OR=1.32, 95% CI 1.04-1.67). For women who began OC use in 1975 or later there was no increased risk.

conclusionsOur findings support that there are modifiable factors for ER-PR- breast cancer and that breastfeeding in particular may mitigate the increased risk of ER-PR- cancers seen from multiparity.

Indexed as

AdultAustraliaBreast FeedingBreast NeoplasmsCaliforniaCase-Control StudiesContraceptives, OralFemaleHumansMiddle AgedOntarioReceptors, EstrogenReceptors, ProgesteroneRegistriesReproductionRisk FactorsContraceptives, OralReceptors, EstrogenReceptors, Progesterone

Identifiers

PMID24548865
PMCPMC3950851
OpenAlexW2023408161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.