ArticleExperimental gerontology2014
Aging and the disposition and toxicity of mercury in rats.
Article in Experimental gerontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- High-Density Lipoproteins (HDLs) contribute to limiting acute tissue damage: proof of concept in a model of mercury-induced nephrotoxicity.Lipids in health and disease · 2026Article
- Associations of Blood and Urinary Heavy Metals with Stress Urinary Incontinence Risk Among Adults in NHANES, 2003-2018.Biological trace element research · 2025Article
- Article
- Sex differences in renal handling of inorganic mercury in aged rats.Current research in toxicology · 2020Article
- Chronic kidney disease in pregnant mothers affects maternal and fetal disposition of mercury.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- Exposure to mixtures of mercury, cadmium, lead, and arsenic alters the disposition of single metals in tissues of Wistar rats.Journal of toxicology and environmental health. Part A · 2018Article
- Disposition of methylmercury over time in a 75% nephrectomized rat model.Journal of toxicology and environmental health. Part A · 2018Article
- Pathophysiological Mechanisms of Renal Fibrosis: A Review of Animal Models and Therapeutic Strategies.In vivo (Athens, Greece) · 2017Review
- The aging kidney and the nephrotoxic effects of mercury.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Mechanisms involved in the transport of mercuric ions in target tissues.Archives of toxicology · 2017Review
- Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice.Environmental health perspectives · 2016Article
- Compensatory renal hypertrophy and the handling of an acute nephrotoxicant in a model of aging.Experimental gerontology · 2016Article
- Article
- Mitochondrial functional impairment in response to environmental toxins in the cardiorenal metabolic syndrome.Archives of toxicology · 2015Review
- Cinnabar induces renal inflammation and fibrogenesis in rats.BioMed research international · 2015Article
- Novel Hg2+-induced nephropathy in rats and mice lacking Mrp2: evidence of axial heterogeneity in the handling of Hg2+ along the proximal tubule.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Progressive loss of functioning nephrons, secondary to age-related glomerular disease, can impair the ability of the kidneys to effectively clear metabolic wastes and toxicants from blood. Additionally, as renal mass is diminished, cellular hypertrophy occurs in functional nephrons that remain. We hypothesize that these nephrons are exposed to greater levels of nephrotoxicants, such as inorganic mercury (Hg(2+)), and thus are at an increased risk of becoming intoxicated by these compounds. The purpose of the present study was to characterize the effects of aging on the disposition and renal toxicity of Hg(2+) in young adult and aged Wistar rats. Paired groups of animals were injected (i.v.) with either a 0.5μmol·kg(-1) non-nephrotoxic or a 2.5μmol·kg(-1) nephrotoxic dose of mercuric chloride (HgCl2). Plasma creatinine and renal biomarkers of proximal tubular injury were greater in both groups of aged rats than in the corresponding groups of young adult rats. Histologically, evidence of glomerular sclerosis, tubular atrophy, interstitial inflammation and fibrosis were significant features of kidneys from aged animals. In addition, proximal tubular necrosis, especially along the straight segments in the inner cortex and outer stripe of the outer medulla was a prominent feature in the renal sections from both aged and young rats treated with the nephrotoxic dose of HgCl2. Our findings indicate 1) that overall renal function is significantly impaired in aged rats, resulting in chronic renal insufficiency and 2) the disposition of HgCl2 in aging rats is significantly altered compared to that of young rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.