ArticleBMC complementary and alternative medicine2014
In vitro metabolism studies of erythraline, the major spiroalkaloid from Erythrina verna.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 17 citations in OpenAlex.
- Environmental and phytohormone modulation of organ-specific specialized metabolite profiles in the dryland tree Erythrina velutina.Plant biology (Stuttgart, Germany) · 2025Article
- Non-target molecular network and putative genes of flavonoid biosynthesis inFrontiers in plant science · 2022Article
- Classification of alkaloids according to the starting substances of their biosynthetic pathways using graph convolutional neural networks.BMC bioinformatics · 2019Article
- Leishmanicidal evaluation of tetrahydroprotoberberine and spirocyclic erythrina-alkaloids.Molecules (Basel, Switzerland) · 2014Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundErythrina verna, popularly known as "mulungu", is a Brazilian medicinal plant used to treat anxiety. Erythrina alkaloids have been described in several species of Erythrina, which have biological and therapeutic properties well known that include anxiolytic and sedative effects.
methodsIn this work, in vitro metabolism of erythraline (1), the major spirocyclic alkaloid of Erythrina verna, was studied in the pig cecum model and by biomimetic phase I reactions. The biomimetic reactions were performed with Jacobsen catalyst to produce oxidative metabolites and one metabolite was isolated and evaluated against cancer cells, as HL-60 (promyelocytic leukemia), SF-295 (Glioblastoma) and OVCAR-8 (ovarian carcinoma).
resultsErythraline exhibited no metabolization by the pig microbiota and a main putative metabolite was formed in a biomimetic model using Jacobsen catalyst. This metabolite was isolated and identified as 8-oxo-erythraline (2). Finally, erythraline and the putative metabolite were tested in MTT model and both compounds showed no important cytotoxic activity against tumor cells.
conclusionsThe alkaloid erythraline was not metabolized by intestinal microbiota, but it was possible to identify its oxidative metabolite from biomimetic reactions. So these data are interesting and stimulate other studies involving this alkaloid, since it is present in phytomedicine products and there are not reported data about the metabolism of erythrina alkaloids.
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