ArticleAssay and drug development technologies
The myImageAnalysis project: a web-based application for high-content screening.
Article in Assay and drug development technologies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy.Nature communications · 2026Article
- A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals.Heliyon · 2024Article
- Machine Learning Methods for Endocrine Disrupting Potential Identification Based on Single-Cell Data.Chemical engineering science · 2023Article
- Sensitive image-based chromatin binding assays using inducible ERα to rapidly characterize estrogenic chemicals and mixtures.iScience · 2022Article
- Quality Control for Single Cell Imaging Analytics Using Endocrine Disruptor-Induced Changes in Estrogen Receptor Expression.Environmental health perspectives · 2022Article
- PRSS50 is a testis protease responsible for proper sperm tail formation and function.Development (Cambridge, England) · 2021Article
- Predicting the Estrogen Receptor Activity of Environmental Chemicals by Single-Cell Image Analysis and Data-driven Modeling.ESCAPE. European Symposium on Computer Aided Process Engineering · 2021Article
- Classification of estrogenic compounds by coupling high content analysis and machine learning algorithms.PLoS computational biology · 2020Article
- A Mechanistic High-Content Analysis Assay Using a Chimeric Androgen Receptor That Rapidly Characterizes Androgenic Chemicals.SLAS discovery : advancing life sciences R & D · 2020Article
- Single-Cell Distribution Analysis of AR Levels by High-Throughput Microscopy in Cell Models: Application for Testing Endocrine-Disrupting Chemicals.SLAS discovery : advancing life sciences R & D · 2020Article
- Article
- Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity.Nucleic acids research · 2020Article
- Leveraging Image-Derived Phenotypic Measurements for Drug-Target Interaction Predictions.Cancer informatics · 2019Article
- Cisplatin generates oxidative stress which is accompanied by rapid shifts in central carbon metabolism.Scientific reports · 2018Article
- Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis.PloS one · 2017Article
- High-Content Screening Identifies Src Family Kinases as Potential Regulators of AR-V7 Expression and Androgen-Independent Cell Growth.The Prostate · 2017Article
- CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy.Hormones & cancer · 2016Article
- Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer.Nature communications · 2016Article
- High throughput microscopy identifies bisphenol AP, a bisphenol A analog, as a novel AR down-regulator.Oncotarget · 2016Article
- Effects of Circular DNA Length on Transfection Efficiency by Electroporation into HeLa Cells.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A major challenge faced by screening centers developing image-based assays is the wide range of assays needed compared to the limited resources that are available to effectively analyze and manage them. To overcome this limitation, we have developed the web-based myImageAnalysis (mIA) application, integrated with an open database connectivity compliant database and powered by Pipeline Pilot (PLP) that incorporates dataset tracking, scheduling and archiving, image analysis, and data reporting. For system administrators, mIA provides automated methods for managing and archiving data. For the biologist, this application allows those without any programming or image analysis experience to quickly develop, validate, and share results of complex image-based assays. Further, the structure of the application within PLP allows those with experience in PLP programming to easily add additional analysis tools as required. The tools within mIA allow users to assess basic (cell count, protein per cell, protein subcellular localization) and more advanced (engineered cell lines analysis, cell toxicity) biological image-based assays that employ advanced statistics and provides key assay performance metrics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.