ArticleProceedings of the National Academy of Sciences of the United States of America1988
Renal autoimmune epitope of group A streptococci specified by M protein tetrapeptide Ile-Arg-Leu-Arg.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Complement-Mediated Kidney Diseases: Role of Alternative Pathway in Glomerular Inflammation.Kidney international reports · 2026Review
- From Infection to Autoimmunity:Microorganisms · 2025Review
- Mechanisms that potentially contribute to the development of post-streptococcal glomerulonephritis.Pathogens and disease · 2024Review
- Article
- Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae.Microbiology spectrum · 2019Review
- Development and characterization of a panel of cross-reactive monoclonal antibodies generated using H1N1 influenza virus.Immunobiology · 2015Article
- Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis.Pediatric nephrology (Berlin, Germany) · 2011Review
- Spa contributes to the virulence of type 18 group A streptococci.Infection and immunity · 2001Article
- Pathogenesis of group A streptococcal infections.Clinical microbiology reviews · 2000Review
- Phosphorylase-cross-reactive antibodies evoked by streptococcal M protein.Infection and immunity · 1990Article
- Vimentin-cross-reactive epitope of type 12 streptococcal M protein.Infection and immunity · 1989Article
- Streptococcal M protein: molecular design and biological behavior.Clinical microbiology reviews · 1989Review
- Influenza viruses induce autoantibodies to a brain-specific 37-kDa protein in rabbit.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Autoimmune sequence of streptococcal M protein shared with the intermediate filament protein, vimentin.The Journal of experimental medicine · 1989Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The renal glomerular cross-reactivity of the amino-terminal region of type 1 streptococcal M protein was investigated. Antisera raised in rabbits against a synthetic peptide representing residues 1-26 and a peptide from which residues 20-22 had been omitted during synthesis were capable not only of opsonizing type 1 streptococci but also of reacting in immunofluorescence tests with human renal glomeruli. The cross-reactions were completely inhibited by the immunizing peptides. By using additional synthetic peptides in these inhibition studies, the glomerular cross-reactive epitope was localized to a tetrapeptide sequence Ile-Arg-Leu-Arg at positions 23-26. A number of synthetic M1 peptides containing the tetrapeptide sequence were inhibitory, whereas the M1 peptides lacking the sequence or unrelated tetrapeptides Arg-Gly-Asp-Ser or Arg-Gly-Phe-Ser were without effect. Furthermore, Ile-Arg-Leu-Arg affinity-purified antibodies reacted with renal glomeruli, and the reactivity was inhibited by the tetrapeptide as well as by type 1 M protein. These results indicate that a renal glomerular autoimmune epitope resides in a tetrapeptide Ile-Arg-Leu-Arg near the amino terminus of type 1 streptococcal M protein.
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Registered trials
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