ArticlePflugers Archiv : European journal of physiology1988
Fast and slowly inactivating components of Ca-channel current and their sensitivities to nicardipine in isolated smooth muscle cells from rat vas deferens.
Article in Pflugers Archiv : European journal of physiology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 45 citations in OpenAlex.
- Nitric oxide-induced biphasic mechanism of vascular relaxation via dephosphorylation of CPI-17 and MYPT1.The Journal of physiology · 2009Article
- Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.Circulation research · 2007Article
- Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations.The Journal of general physiology · 1996Article
- Modulation of calcium channel currents by arachidonic acid in single smooth muscle cells from vas deferens of the guinea-pig.British journal of pharmacology · 1995Article
- Properties of inactivation of calcium channel currents in smooth muscle cells of rabbit portal vein.Pflugers Archiv : European journal of physiology · 1994Article
- Blockade by calmodulin inhibitors of Ca2+ channels in smooth muscle from rat vas deferens.British journal of pharmacology · 1993Article
- Effects of calcitonin gene-related peptide (CGRP) on Ca(2+)-channel current of isolated smooth muscle cells from rat vas deferens.Naunyn-Schmiedeberg's archives of pharmacology · 1992Article
- Low dihydropyridine receptor density in vasa deferentia of castrated rats.British journal of pharmacology · 1992Article
- Characterization of divalent cation-induced [3H]acetylcholine release from EGTA-treated rat hippocampal synaptosomes.Neurochemical research · 1991Article
- Effects of 2,3-butanedione monoxime on whole-cell Ca2+ channel currents in single cells of the guinea-pig taenia caeci.The Journal of physiology · 1991Article
- Inactivation kinetics and pharmacology distinguish two calcium currents in mouse pancreatic B-cells.The Journal of membrane biology · 1991Article
- Voltage-dependent sodium and potassium, but no calcium conductances in DDT1 MF-2 smooth muscle cells.Pflugers Archiv : European journal of physiology · 1991Article
- An ATP-activated conductance in pheochromocytoma cells and its suppression by extracellular calcium.The Journal of physiology · 1990Article
- The whole-cell Ca2+ channel current in single smooth muscle cells of the guinea-pig ureter.The Journal of physiology · 1990Article
- Calcium channel current and its sensitivity to (+) isradipine in cultured pregnant rat myometrial cells. An electrophysiological and a binding study.Pflugers Archiv : European journal of physiology · 1989Article
- Multiple types of voltage-dependent Ca channels in mammalian intestinal smooth muscle cells.Pflugers Archiv : European journal of physiology · 1989Article
- Calcium current inactivation in insulin-secreting cells is mediated by calcium influx and membrane depolarization.Pflugers Archiv : European journal of physiology · 1989Article
- Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Fast and slowly inactivating components of Ca-channel current were compared to clarify whether more than one type of Ca-channel exists in smooth muscle cells from rat vas deferens using the whole cell variant of the patch clamp technique. The pipette was filled with 150 mM Cs solution to eliminate outward current and Ba was used as the charge carrier for Ca-channel current. (2) When activated by a 5 s test pulse to O mV from a holding potential of -60 mV, the inactivation process of Ba-current was well fitted by the sum of two exponentials. The time constant of the faster inactivating component was 100-300 s and that of the slower inactivating component was 1.5-3 s. Steady-state inactivation curves of the fast- and slow-components were very similar. (3) The inward current activated at O mV from -80 mV was inactivated faster than that from -30 mV. The voltage-dependencies of the peak current from holding potentials of -30 mV and -80 mV were similar. Both had voltage threshold at -30 mV and were maximal at +10 mV. (4) Low concentrations of nicardipine (10(-9) to 10(-7) M) preferentially inhibited the slow component while higher concentration (10(-6) to 10(-5) M) were required to block the fast component. The current activated from a holding potential of -30 mV was almost fully suppressed by 10(-7) M nicardipine whereas that from -80 mV was blocked only slightly.(ABSTRACT TRUNCATED AT 250 WORDS)
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