ArticleEnvironmental and molecular mutagenesis2014
Epigenetic alterations induced by ambient particulate matter in mouse macrophages.
Article in Environmental and molecular mutagenesis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Short-term diesel exhaust inhalation in a controlled human crossover study is associated with changes in DNA methylation of circulating mononuclear cells in asthmatics.Particle and fibre toxicology · 2014Trial
- Immune-Epigenetic Effects of Environmental Pollutants: Mechanisms, Biomarkers, and Transgenerational Impact.Current issues in molecular biology · 2025Review
- Climate Change and New Challenges for Rural Communities: Particulate Matter Matters.Sustainability · 2023Article
- Folate metabolism modifies chromosomal damage induced by 1,3-butadiene: results from a match-up study in China and in vitro experiments.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis.Environmental science and pollution research international · 2021Review
- Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?Clinical epigenetics · 2019Review
- Review
- Histone 3 modifications and blood pressure in the Beijing Truck Driver Air Pollution Study.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2017Article
- Oxidative stress and repetitive element methylation changes in artisanal gold miners occupationally exposed to mercury.Heliyon · 2017Article
- Article
- Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study.Environmental research · 2017Article
- Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System.Journal of visualized experiments : JoVE · 2016Article
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.Mutation research · 2016Article
- Effects of Laser Printer-Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymphoblasts.Environmental health perspectives · 2016Article
- Article
- In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles.Nanotoxicology · 2016Article
- Short-term exposure to engineered nanomaterials affects cellular epigenome.Nanotoxicology · 2016Article
- In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung.Life sciences in space research · 2015Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Respiratory mortality and morbidity has been associated with exposure to particulate matter (PM). Experimental evidence suggests involvement of cytotoxicity, oxidative stress, and inflammation in the development of PM-associated pathological states; however, the exact mechanisms remain unclear. In the current study, we analyzed short-term epigenetic response to PM10 (particles with aerodynamic diameter less than 10 μm) exposure in mouse ascitic RAW264.7 macrophages (BALB/C Abelson murine leukemia virus-induced tumor). Ambient PM10 was collected using a high volume sampler in Little Rock, AR. Analysis revealed that PM10 was composed mainly of Al and Fe, and the water soluble organic fraction was dominated by aliphatic and carbohydrate fragments and minor quantities of aromatic components. Exposure to PM10 compromised the cellular epigenome at concentrations 10-200 µg/ml. Specifically, epigenetic alterations were evident as changes in the methylation and expression of repetitive element-associated DNA and associated DNA methylation machinery. These results suggest that epigenetic alterations, in concert with cytotoxicity, oxidative stress, and inflammation, might contribute to the pathogenesis of PM-associated respiratory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.