ArticleVirchows Archiv : an international journal of pathology2014
Reproducibility of histopathologic tumor grading in penile cancer--results of a European project.
Article in Virchows Archiv : an international journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Retrospective Single Center Assessment of Routes to Penile Cancer Diagnosis and the Role of Penile Biopsy.International journal of urology : official journal of the Japanese Urological Association · 2026Observational
- New histological risk grading system for prediction of lymph node metastasis in patients with penile cancer.Virchows Archiv : an international journal of pathology · 2025Article
- Article
- Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer.Journal of cancer research and clinical oncology · 2022Article
- Low level of interobserver concordance in assessing histological subtype and tumor grade in patients with penile cancer may impair patient care.Virchows Archiv : an international journal of pathology · 2022Article
- Global research trends in penile cancer: Bibliometric and visualized analysis.Frontiers in oncology · 2022Article
- The Clinical Complexity of Penile Cancer: Current Clinical-Epidemiological Data from the Database of the Free State of Saxony/Germany.Urologia internationalis · 2022Article
- [Conventional grading vs. molecular grading : Decision aids for clinical routine].Der Urologe. Ausg. A · 2021Review
- Challenging the prognostic impact of the new WHO and TNM classifications with special emphasis on HPV status in penile carcinoma.Virchows Archiv : an international journal of pathology · 2019Article
- [Molecular tumor board penile cancer-a challenge].Der Urologe. Ausg. A · 2019Review
- The Diagnosis and Treatment of Penile Cancer.Deutsches Arzteblatt international · 2018Article
- [Pathology and histopathological evaluation of penile cancer].Der Urologe. Ausg. A · 2018Review
- Contemporary management of patients with penile cancer and lymph node metastasis.Nature reviews. Urology · 2017Review
- Strong association of insulin-like growth factor 1 receptor expression with histologic grade, subtype, and HPV status in penile squamous cell carcinomas: a tissue microarray study of 112 cases.Virchows Archiv : an international journal of pathology · 2017Article
- The role of histologic subtype, p16(INK4a) expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma.BMC cancer · 2015Article
- [Organ-preserving therapy for penile carcinoma].Der Urologe. Ausg. A · 2014Article
- Predictive histopathological factors of nodal metastasis in penile cancer.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
14 authors at 9 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since reliable molecular prognostic parameters for inguinal lymph metastases in penile cancer are not available, tumor grading is often used as a surrogate prognostic tool for the indication of inguinal lymphadenctomy and has been integrated into the current TNM classification for penile cancer. The reliability of tumor grading is under discussion. We examined interobserver grading variability in 90 primary penile carcinomas, assessed by 12 different uropathologists from five European countries. Tumor grading, following the CAP scheme, was compared, and interobserver variability was calculated using kappa statistics. The interobserver variability was high as reflected by an overall low kappa coefficient (mean k = 0.34) and reached a moderate level only in 26.4 % of the cases (range 0.02-0.67). The percentage of G1 tumors assigned ranged from 8.6 to 52.5 %, G2 tumors from 27.1 to 72.6 % and G3 tumors from 11.7 to 48.7 %. Only some observers assigned G4 with a range of 0.6-21.9 %. Subdivision into low and high grade according to UICC and EAU classifications differed significantly (P < 0.001). Low reproducibility of grading in penile carcinomas with the favored method does not allow a reliable prognostication of tumor aggressiveness. Inclusion of histological grading into the TNM classification currently seems not to be a benefit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.