ArticlePflugers Archiv : European journal of physiology2014
Beta-adrenergic stimulation reverses the I Kr-I Ks dominant pattern during cardiac action potential.
Article in Pflugers Archiv : European journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- The utility of the T wave peak to T wave end interval to Q-T end interval ratio as a dynamic indicator of cardiac sympathetic activity: a preliminary study.Heart and vessels · 2026Article
- Beta2-adrenergic receptor activation increases susceptibility to arrhythmogenesis in aging heart by impairing repolarization reserve via GScientific reports · 2026Article
- T-World Virtual Human Cardiomyocyte. I. Development, Validation, and Cell Arrhythmogenesis.Circulation research · 2026Article
- Strategies for prolonging ventricular action potential duration without increasing transmural dispersion of repolarization.Physiological reports · 2025Article
- Predicting the Damaging Potential of UncharacterizedInternational journal of molecular sciences · 2025Article
- Smoking-associated electrocardiographic abnormalities predict cardiovascular mortality.Scientific reports · 2024Article
- Connecting transcriptomics with computational modeling to reveal developmental adaptations in pediatric human atrial tissue.American journal of physiology. Heart and circulatory physiology · 2024Article
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- Pharmacological Screening of Kv7.1 and Kv7.1/KCNE1 Activators as Potential Antiarrhythmic Drugs in the Zebrafish Heart.International journal of molecular sciences · 2023Article
- Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes.Physiological reports · 2023Article
- Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- IBiomedicines · 2023Article
- A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Action potential responses to changes in stimulation frequency and isoproterenol in rat ventricular myocytes.Physiological reports · 2022Article
- Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique.Frontiers in physiology · 2022Review
- Characterization and functional role of rapid- and slow-activating delayed rectifier KPflugers Archiv : European journal of physiology · 2021Article
- Delayed KCNQ1/KCNE1 assembly on the cell surface helps IThe Journal of physiology · 2021Article
- Dynamics of adrenergic signaling in cardiac myocytes and implications for pharmacological treatment.Journal of theoretical biology · 2021Article
- Abnormal Cardiac Repolarization in Thyroid Diseases: Results of an Observational Study.Frontiers in cardiovascular medicine · 2021Article
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6 authors.
Funding
Abstract
β-Adrenergic stimulation differentially modulates different K(+) channels and thus fine-tunes cardiac action potential (AP) repolarization. However, it remains unclear how the proportion of I Ks, I Kr, and I K1 currents in the same cell would be altered by β-adrenergic stimulation, which would change the relative contribution of individual K(+) current to the total repolarization reserve. In this study, we used an innovative AP-clamp sequential dissection technique to directly record the dynamic I Ks, I Kr, and I K1 currents during the AP in guinea pig ventricular myocytes under physiologically relevant conditions. Our data provide quantitative measures of the magnitude and time course of I Ks, I Kr, and I K1 currents in the same cell under its own steady-state AP, in a physiological milieu, and with preserved Ca(2+) homeostasis. We found that isoproterenol treatment significantly enhanced I Ks, moderately increased I K1, but slightly decreased I Kr in a dose-dependent manner. The dominance pattern of the K(+) currents was I Kr > I K1 > I Ks at the control condition, but reversed to I Kr < I K1 < I Ks following β-adrenergic stimulation. We systematically determined the changes in the relative contribution of I Ks, I Kr, and I K1 to cardiac repolarization during AP at different adrenergic states. In conclusion, the β-adrenergic stimulation fine-tunes the cardiac AP morphology by shifting the power of different K(+) currents in a dose-dependent manner. This knowledge is important for designing antiarrhythmic drug strategies to treat hearts exposed to various sympathetic tones.
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