Evidence map›Paper›PMID 24535549›Full record

SynthesisSchizophrenia bulletin2014

Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia.

Akira Nishi, Shusuke Numata, Atsushi Tajima, Makoto Kinoshita, Kumiko Kikuchi, Shinji Shimodera, Masahito Tomotake, Kazutaka Ohi, Ryota Hashimoto, Issei Imoto and 2 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 9 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 9 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Akira NishiDepartment of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan;
Shusuke NumataDepartment of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan; shu-numata@umin.ac.jp.
Atsushi TajimaDepartment of Human Genetics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan;
Makoto KinoshitaDepartment of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan;
Kumiko KikuchiDepartment of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan;
Shinji ShimoderaDepartment of Neuropsychiatry, Kochi Medical School, Kochi University, Kochi, Japan;
Masahito TomotakeDepartment of Mental Health, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan;
Kazutaka OhiDepartment of Psychiatry, Osaka University Graduate school of Medicine, Osaka, Japan;
Ryota HashimotoDepartment of Psychiatry, Osaka University Graduate school of Medicine, Osaka, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.
Issei ImotoDepartment of Human Genetics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan;
Masatoshi TakedaDepartment of Psychiatry, Osaka University Graduate school of Medicine, Osaka, Japan;
Tetsuro OhmoriDepartment of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan;
Tokushima University · JPOsaka University · JPKōchi University · JPOsaka City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies suggest that elevated blood homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism are risk factors for schizophrenia. However, the effects of gender and MTHFR C677T genotypes on blood homocysteine levels in schizophrenia have not been consistent. We first investigated whether plasma total homocysteine levels were higher in patients with schizophrenia than in controls with stratification by gender and by the MTHFR C677T genotypes in a large cohort (N = 1379). Second, we conducted a meta-analysis of association studies between blood homocysteine levels and schizophrenia separately by gender (N = 4714). Third, we performed a case-control association study between the MTHFR C677T polymorphism and schizophrenia (N = 4998) and conducted a meta-analysis of genetic association studies based on Japanese subjects (N = 10 378). Finally, we assessed the effect of plasma total homocysteine levels on schizophrenia by a mendelian randomization approach. The ANCOVA after adjustment for age demonstrated a significant effect of diagnosis on the plasma total homocysteine levels in all strata, and the subsequent meta-analysis for gender demonstrated elevated blood homocysteine levels in both male and female patients with schizophrenia although antipsychotic medication might influence the outcome. The meta-analysis of the Japanese genetic association studies demonstrated a significant association between the MTHFR C677T polymorphism and schizophrenia. The mendelian randomization analysis in the Japanese populations yielded an OR of 1.15 for schizophrenia per 1-SD increase in plasma total homocysteine. Our study suggests that increased plasma total homocysteine levels may be associated with an increased risk of schizophrenia.

Indexed as

Genetic Association StudiesAdultAgedCase-Control StudiesCohort StudiesFemaleGenotypeHomocysteineHumansJapanMaleMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedPolymorphism, GeneticSchizophreniaSex FactorsHomocysteineMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanJapanesemendelian randomizationplasma homocysteineSNP

Identifiers

PMID24535549
PMCPMC4133669
OpenAlexW2163807154

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.