ArticleJournal of neurology2014
Do eye movement impairments in patients with small vessel cerebrovascular disease depend on lesion load or on cognitive deficits? A video-oculographic and MRI study.
Article in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Pooled it
- Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Large diameter hemicraniectomy does not improve long-term outcome in malignant infarction.Journal of neurology · 2023Trial
- Saccadic Oscillations After Donepezil Administration in Patients with Dementia: Time Course and Clinical Correlates.Journal of eye movement research · 2026Article
- [Correlation between eye movement and white matter hyperintensity characteristics in patients with cerebral small vessel disease].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Eye movement characteristics and their correlation with cognitive function in cerebral small vessel disease.Frontiers in neurology · 2026Article
- Gait performance in cerebral small vessel disease: associations with cognitive and oculomotor function and exploratory mediation analyses.Frontiers in aging neuroscience · 2026Article
- The vestibular and oculomotor dysfunction in Fabry disease: a cohort study in China.Annals of medicine · 2025Article
- Artificial intelligence-assisted oculo-gait measurements for cognitive impairment in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease.Biomedicines · 2022Article
- Eye movement alterations in presymptomatic C9orf72 expansion gene carriers.Journal of neurology · 2021Article
- Diagnostic value of video-oculography in progressive supranuclear palsy: a controlled study in 100 patients.Journal of neurology · 2021Article
- Optical coherence tomography-based assessment of retinal vascular pathology in cerebral small vessel disease.Neurological research and practice · 2020Article
- Structural brain signature of cognitive decline in Parkinson's disease: DTI-based evidence from the LANDSCAPE study.Therapeutic advances in neurological disorders · 2019Article
- Structural and Functional Brain Mapping Correlates of Impaired Eye Movement Control in Parkinsonian Syndromes: A Systems-Based Concept.Frontiers in neurology · 2018Review
- Regional microstructural damage and patterns of eye movement impairment: a DTI and video-oculography study in neurodegenerative parkinsonian syndromes.Journal of neurology · 2017Article
- Aging with Cerebral Small Vessel Disease and Dizziness: The Importance of Undiagnosed Peripheral Vestibular Disorders.Frontiers in neurology · 2017Article
- Eye-tracking controlled cognitive function tests in patients with amyotrophic lateral sclerosis: a controlled proof-of-principle study.Journal of neurology · 2015Article
- Eye Movement Deficits Are Consistent with a Staging Model of pTDP-43 Pathology in Amyotrophic Lateral Sclerosis.PloS one · 2015Article
- Individual differences in oscillatory brain activity in response to varying attentional demands during a word recall and oculomotor dual task.Frontiers in human neuroscience · 2015Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small vessel cerebrovascular disease (SVCD) is one of the most frequent vessel disorders in the aged brain. Among the spectrum of neurological disturbances related to SVCD, oculomotor dysfunction is a not well understood symptom- in particular, it remains unclear whether vascular lesion load in specific brain regions affects oculomotor function independent of cognitive decline in SVCD patients or whether the effect of higher brain function deficits prevails. In this study, we examined a cohort of 25 SVCD patients and 19 healthy controls using video-oculographic eye movement recording in a laboratory environment, computer-based MRI assessment of white matter lesion load (WMLL), assessment of extrapyramidal motor deficits, and psychometric testing. In comparison to controls, the mean WMLL of patients was significantly larger than in controls. With respect to eye movement control, patients performed significantly worse than controls in almost all aspects of oculomotion. Likewise, patients showed a significantly worse performance in all but one of the neuropsychological tests. Oculomotor deficits in SVCD correlated with the patients' cognitive dysfunctioning while there was only weak evidence for a direct effect of WMLL on eye movement control. In conclusion, oculomotor impairment in SVCD seems to be mainly contingent upon cognitive deterioration in SVCD while WMLL might have only a minor specific effect upon oculomotor pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.