ArticleJournal of neurology2014
White matter lesions in chronic migraine with medication overuse headache: a cross-sectional MRI study.
Article in Journal of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis.NeuroImage. Clinical · 2023Pooled it
- Association of LTA and SOD Gene Polymorphisms with Cerebral White Matter Hyperintensities in Migraine Patients.International journal of molecular sciences · 2022Article
- The Characteristics of White Matter Hyperintensities in Patients With Migraine.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study.Arquivos de neuro-psiquiatria · 2021Article
- Cognitive Function and White Matter Lesions in Medication-Overuse Headache.Journal of pain research · 2021Article
- Regional volume changes of the brain in migraine chronification.Neural regeneration research · 2020Article
- Whole-Brain Myelin Imaging Using 3D Double-Echo Sliding Inversion Recovery Ultrashort Echo Time (DESIRE UTE) MRI.Radiology · 2020Article
- Mechanisms of migraine as a chronic evolutive condition.The journal of headache and pain · 2019Review
- Cognitive Decline in Chronic Migraine with Nonsteroid Anti-inflammation Drug Overuse: A Cross-Sectional Study.Pain research & management · 2019Article
- Analysis of alterations in white matter integrity of adult patients with comitant exotropia.The Journal of international medical research · 2018Article
- Evaluation of white matter hyperintensities and retinal fiber layer, ganglion cell layer, inner-plexiform layer, and choroidal layer in migraine patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Neuroimaging Findings in Patients with Medication Overuse Headache.Current pain and headache reports · 2018Review
- Brain structural investigation and hippocampal tractography in medication overuse headache: a native space analysis.Behavioral and brain functions : BBF · 2017Article
- Cortical thickness and functional connectivity abnormality in chronic headache and low back pain patients.Human brain mapping · 2017Article
- Recent neuroimaging advances in the study of primary headaches.Current pain and headache reports · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analgesic overuse often happens to migraine patients, especially chronic migraineurs, and migraine has been demonstrated to be associated with white matter lesions (WMLs). The aim of this study was to investigate the relationship between medication overuse headache (MOH) and WMLs in chronic migraine (CM) patients. Subjects were enrolled and divided into three groups: healthy controls, CM without MOH (CMwoMOH), and CM with MOH (CM-MOH). Most of the CM patients used non-steroidal anti-inflammatory drugs (NSAIDs) as acute headache medications. All the participants underwent magnetic resonance imaging scans and images were obtained for WML evaluation with semiquantitative scales. One hundred and forty-one participants were included, 45 of them for controls, 38 for CMwoMOH, and 58 for CM-MOH. In women, CMwoMOH patients had a higher prevalence of high WML load compared with controls and CM-MOH patients. In men, however, all the study groups showed no differences in the prevalence of high WML load. CMwoMOH women had increased risks of high deep white matter lesion (DWML) load compared with controls, while they had no risks of high periventricular white matter lesion (PVWML) load. CM-MOH women had no risks of high DWML load, but they had reduced risks of high PVWML load. The association of CM-MOH with high WML load in women was not changed when compared with CMwoMOH. Age was independently associated with high WML load among women. These data suggest that MOH caused by NSAIDs is not a risk factor for WMLs. Rather, NSAID overuse probably protects MOH patients from WMLs through anti-inflammatory effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.