ArticleClinical oral investigations2014
Analysis of reasons for osteonecrosis of the jaws.
Article in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is serum C-terminal telopeptide cross-link of type 1 collagen a reliable parameter for predicting the risk of medication-related osteonecrosis of the jaws? A systematic review and meta-analysis of diagnostic test accuracy.Clinical oral investigations · 2022Pooled it
- A case series and review of canine idiopathic osteonecrosis of the jaw.Frontiers in veterinary science · 2025Article
- Medication-Related Osteonecrosis: Why the Jawbone?Dentistry journal · 2023Review
- Effect of systemic antiresorptive medication on the histopathological parameters of implant osseointegration in an in vivo rodent study.BMC oral health · 2023Article
- [Bisphosphonate-related osteonecrosis of the jaw caused by implant: a case report].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Article
- Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis.Journal of translational medicine · 2019Article
- Clinical analysis of medication related osteonecrosis of the jaws: A growing severe complication in China.Journal of dental sciences · 2018Article
- Effects of an oral bisphosphonate and three intravenous bisphosphonates on several cell types in vitro.Clinical oral investigations · 2018Article
- Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis.Journal of translational medicine · 2017Article
- A retrospective study of osteomyelitis and osteonecrosis of the jaws and its etiologic implication of bisphosphonate in Asians.Clinical oral investigations · 2017Article
- The influence of geranylgeraniol on microvessel sprouting after bisphosphonate substitution in an in vitro 3D-angiogenesis assay.Clinical oral investigations · 2017Article
- Osteonecrosis of the Jaw (ONJ) in Osteoporosis Patients: Report of Delayed Diagnosis of a Multisite Case and Commentary about Risks Coming from a Restricted ONJ Definition.Dentistry journal · 2017Article
- Angiogenesis in the Development of Medication-Related Osteonecrosis of the Jaws: An Overview.Dentistry journal · 2016Review
- Dental implants in patients treated with antiresorptive medication - a systematic literature review.International journal of implant dentistry · 2016Review
- Diabetes Mellitus and Its Association to the Occurrence of Medication-Related Osteonecrosis of the Jaw.Dentistry journal · 2016Article
- Bone scintigraphy predicts bisphosphonate-induced osteonecrosis of the jaw (BRONJ) in patients with metastatic castration-resistant prostate cancer (mCRPC).Clinical oral investigations · 2016Article
- Article
- Isoprenoid geranylgeraniol: the influence on cell characteristics of endothelial progenitor cells after bisphosphonate therapy in vitro.Clinical oral investigations · 2015Article
- Non-Radiation-Related Osteonecrosis of the Jaws in Dogs: 14 Cases (1996-2014).Frontiers in veterinary science · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteonecroses of the jaws are caused by several reasons. Bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) is known since 2003 with an increasing incidence in the first years. Along with more knowledge about the pathophysiology, preventive strategies were implemented trying to reduce the incidence. The aim of this retrospective study was to analyze the frequency and overall proportion of BP-ONJ within the field of osteonecrosis. The data was compared to a similar study performed in 2005.
methodsAll patients with osteonecrosis or osteomyelitis treated in the period from April 2005 to July 2012 in the Oral and Maxillofacial Surgery at the University of Mainz, Germany, were analyzed.
resultsThe reasons for osteonecrosis were bisphosphonates in 45 %, odontogenic or surgically induced osteonecrosis in 32 %, osteoradionecrosis in 17 %, traumas in 1 %, and in 4 % the reason remained unclear. The BP-ONJ became the most important factor for osteonecrosis. Its fraction in the years 2000-2005 was 10 % only.
conclusionsAlthough preventive strategies are implemented, the number of new cases got bigger. The implemented prevention strategies did not manage to reduce the overall number of new cases. Furthermore, the launch of other medications with a similar side effect on the jawbone as the BP-ONJ for bisphosphonates might influence the overall distribution of osteonecroses.
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