Evidence map›Paper›PMID 24535067›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2014

Prevention of etomidate-induced myoclonus: which is superior: Fentanyl, midazolam, or a combination? A Retrospective comparative study.

Ilke Isitemiz, Sinan Uzman, Mehmet Toptaş, Ayşe Vahapoglu, Yaşar Gökhan Gül, Ferda Yilmaz Inal, Ibrahim Akkoc

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  10. Etomidate-remifentanil is more suitable for monitored anesthesia care during gastroscopy in older patients than propofol-remifentanil.Medical science monitor : international medical journal of experimental and clinical research · 2015
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  17. Acute Movement Disorders in Childhood.Journal of clinical medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ilke IsitemizDepartment of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, Turkey.
Sinan UzmanDepartment of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, Turkey.
Mehmet ToptaşDepartment of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, Turkey.
Ayşe VahapogluDepartment of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, Turkey.
Yaşar Gökhan GülDepartment of Anesthesiology and Reanimation, Kosuyolu High Speciality Training and Research Hospital, Istanbul, Turkey.
Ferda Yilmaz InalDepartment of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, Turkey.
Ibrahim AkkocDepartment of Anesthesiology and Reanimation, Haseki Training and Research Hospital, Istanbul, Turkey.
Haseki Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. MATERIAL AND

methodsThis study was performed based on anesthesia records. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated into 4 groups: no pretreatment (Group NP), fentanyl 1 µg·kg-1 (Group F), midazolam 0.03 mg·kg-1 (Group M), and midazolam 0.015 mg·kg-1 + fentanyl 0.5 µg·kg-1 (Group FM). Patients who received the same anesthetic procedure were selected: 2 minutes after intravenous injections of the pretreatment drugs, anesthesia is induced with 0.3 mg·kg-1 etomidate injected intravenously over a period of 20-30 seconds. Myoclonic movements are evaluated, which were observed and graded according to clinical severity during the 2 minutes after etomidate injection. The severity of pain due to etomidate injection, mean arterial pressure, heart rate, and adverse effects were also evaluated.

resultsStudy results showed that myoclonus incidence was 85%, 40%, 70%, and 25% in Group NP, Group F, Group M, and Group FM, respectively, and were significantly lower in Group F and Group FM.

conclusionsWe conclude that pretreatment with fentanyl or combination of fentanyl and midazolam was effective in preventing etomidate-induced myoclonus.

Indexed as

Anesthetics, IntravenousBlood PressureDrug Therapy, CombinationEtomidateFentanylHeart RateHumansMidazolamMyoclonusRetrospective StudiesStatistics, NonparametricAnesthetics, IntravenousEtomidateFentanylMidazolam

Identifiers

PMID24535067
PMCPMC3930766
OpenAlexW2036327842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.