ArticleLab on a chip2014
Cooperative roles of biological flow and surface topography in guiding sperm migration revealed by a microfluidic model.
Article in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microfluidic chips in female reproduction: a systematic review of status, advances, and challenges.Theranostics · 2024Pooled it
- Let the female tract choose: finding the sperm to enhanceAnimal reproduction · 2026Article
- Simple and rapid microfluidic device for processing raw human semen and separation of motile sperm based on their intrinsic behavior and morphology.Scientific reports · 2025Article
- Hybrid motility mechanism of sperm at viscoelastic fluid-solid interface.Scientific reports · 2024Article
- Advances in microfluidic technology for sperm screening and in vitro fertilization.Analytical and bioanalytical chemistry · 2024Review
- Hybrid motility mechanism of sperm at viscoelastic-solid interface.Research square · 2024Article
- Microfluidic chip as a promising evaluation method in assisted reproduction: A systematic review.Bioengineering & translational medicine · 2024Review
- A novel microfluidic device with parallel channels for sperm separation using spermatozoa intrinsic behaviors.Scientific reports · 2023Article
- Lab-on-chip (LoC) application for quality sperm selection: An undelivered promise?Open research Europe · 2023Review
- Squirmer hydrodynamics near a periodic surface topography.Frontiers in cell and developmental biology · 2023Article
- Biological benefits of collective swimming of sperm in a viscoelastic fluid.Frontiers in cell and developmental biology · 2022Article
- The influence of the female reproductive tract and sperm features on the design of microfluidic sperm-sorting devices.Journal of assisted reproduction and genetics · 2022Review
- Migration of active filaments under Poiseuille flow in a microcapillary tube.The European physical journal. E, Soft matter · 2021Article
- Curvature in the reproductive tract alters sperm-surface interactions.Nature communications · 2021Article
- Review
- Modelling Motility: The Mathematics of Spermatozoa.Frontiers in cell and developmental biology · 2021Review
- Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane CaThe EMBO journal · 2020Article
- Hyperactivated stallion spermatozoa fail to exhibit a rheotaxis-like behaviour, unlike other species.Scientific reports · 2018Article
- Rheotaxis-based separation of sperm with progressive motility using a microfluidic corral system.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Live births from artificial insemination of microfluidic-sorted bovine spermatozoa characterized by trajectories correlated with fertility.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Successful reproduction in mammals requires sperm to swim against a fluid flow and through the long and complex female reproductive tract before reaching the egg in the oviduct. Millions of them do not make it. Despite their clinical importance, the roles played in sperm migration by the diverse biophysical and biochemical microenvironments within the reproductive tract are largely unknown. In this article, we present the development of a double layer microfluidic device that recreates two important biophysical environments within the female reproductive tract: fluid flow and surface topography. The unique feature of the device is that it enables one to study the cooperative roles of fluid flow and surface topography in guiding sperm migration. Using bull sperm as a model system, we found that microfluidic grooves embedded on a channel surface facilitate sperm migration against fluid flow. These findings suggest ways to design in vitro fertilization devices to treat infertility and to develop non-invasive contraceptives that use a microarchitectural design to entrap sperm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.