ArticleMarine drugs2014
Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5'-methylthioinosine from a Ghanaian Micromonospora sp. K310.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential.Chembiochem : a European journal of chemical biology · 2026Review
- Metabolomic and genomic insights into Micromonospora carbonacea subsp. caeruleus for anti-colorectal compound.Applied microbiology and biotechnology · 2025Article
- Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity.Applied and environmental microbiology · 2024Article
- Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities.Marine drugs · 2022Review
- The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987-2020).Marine life science & technology · 2021Review
- Antimicrobial compounds from marine actinomycetes.Archives of pharmacal research · 2020Review
- The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms.Marine drugs · 2020Review
- Bulbiferates A and B: Antibacterial Acetamidohydroxybenzoates from a Marine Proteobacterium,Journal of natural products · 2019Article
- Three New Isoflavonoid Glycosides from the Mangrove-Derived ActinomyceteMarine drugs · 2019Article
- Marine Rare Actinomycetes: A Promising Source of Structurally Diverse and Unique Novel Natural Products.Marine drugs · 2019Review
- Marine Macrolides with Antibacterial and/or Antifungal Activity.Marine drugs · 2019Review
- Bioactivities and molecular networking-based elucidation of metabolites of potent actinobacterial strains isolated from the Unkeshwar geothermal springs in India.RSC advances · 2019Article
- Puromycins B-E, Naturally Occurring Amino-Nucleosides Produced by the Himalayan Isolate Streptomyces sp. PU-14G.Journal of natural products · 2018Article
- Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams.Chemical science · 2017Article
- Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase.Scientific reports · 2017Article
- Diverse Cone-Snail Species Harbor Closely RelatedFrontiers in microbiology · 2017Article
- Endophytic Actinobacteria and the Interaction of Micromonospora and Nitrogen Fixing Plants.Frontiers in microbiology · 2015Review
- Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity.Frontiers in microbiology · 2015Review
- New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.Marine drugs · 2014Article
- Natural products from mangrove actinomycetes.Marine drugs · 2014Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5'-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes.
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